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Biomedical subjects

R B Bauer

Publications and source records attributed to R B Bauer.

18 recordsLinked to original sources

L-dopa treatment of Parkinson's disease: a ten-year follow up study.

A ten-year follow-up study of parkinsonian patients treated with L-dopa is presented. Originally 130 patients entered the study, and previous reports were presented in 1971 and 1973. This report concerns the 47 remaining patients now available for examination. The effectiveness of L-dopa diminished over the ten-year period, so that the disability states of these patients are now similar to those prevailing just before the study began ten years ago. Despite the decline, the interim improvement and the patients' relatively asymptomatic existence for part of the time confirm the effectiveness of L-dopa therapy in the treatment of Parkinson's disease.

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Vertebral artery reconstruction. A successful technique in selected patients.

Fourteen patients were selected to have a total of 15 vertebral artery reconstructions in a four-year period. They all had incapacitating neurologic symptoms, and detailed investigations had been done to rule out other possible causes. If more than one lesion was present in the angiogram, priority was given to the reconstruction of carotid lesions. If symptoms persisted, vertebral artery stenoses were considered significant only if they involved greater than or equal to 75% of the cross-sectional area with the other vertebral artery being equally diseased or absent. The preferred operation was a vertebral artery bypass, although four reimplantations were done. Postoperative angiograms showed all grafts to be patent. Patency was confirmed again at 28 +/- 16 SD months by Doppler imaging. There were no operative neurologic deficits or deaths. All patients but one (in whom the selection protocol was not followed strictly) were relieved of their incapacitating symptoms.

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Bilateral internal carotid artery occlusion. Its surgical management.

Seven patients with symptomatic bilateral internal carotid artery occlusion had 11 extracranial operations involving carotid, vertebral, and subclavian arteries. A priority approach to the extracranial vessels was followed. Priority was given to the correction of subclavian steal when present. An external carotid angioplasty or bypass was given priority if its origin was stenotic or occluded. If both vertebral arteries, or the dominant one, had stenoses at their origin greater than 75% of the cross-sectional area, a subclavian-vertebral artery bypass was performed. When both internal carotid arteries are occluded, the external carotid and vertebrovasilar systems are the main collaterals and are often also stenotic. Correction of these occlusive lesions in the collateral pathways produced complete symptomatic relief in these patients. In two selected cases with specific angiographic findings and a normal blood pressure, immediate internal carotid thromboendarterectomy was performed. No morbidity or mortality was encountered in these seven patients.

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Subclavian artery to external carotid artery bypass graft. Improvement of cerebral blood supply.

External carotid flow may contribute a substantial amount of cerebral flow via collaterals in cases of internal carotid artery occlusion. When common and internal carotid arteries are occluded, the distal portion of the external carotid artery is kept open by collateral flow. Revascularization of the external carotid by means of a bypass graft from the subclavian artery will improve the blood flow through collateral vessels connecting the external and internal carotid territories, and thus increase the cerebral blood supply from the branches of the external carotid artery.

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Vertebral artery bypass.

The origin of the vertebral artery is a frequent site for the development of stenosing lesions. The flow deficit caused by the stenosis of one vertebral artery is normally compensated for by intracranial anastomosis between the carotid and basilar arteries or by the opposite vertebral artery. A number of patients, however, have inadequate intracranial anastomosis and hypoplasia or stenosis of the opposite vertebral artery, and symptoms of brain ischemia develop. We describe here four cases in which a new technique, a subclavian vertebral artery autogenous vein bypass graft, was used to deal with the diseased segment of the vertebral artery. Transient postoperative problems included lymphocele and Horner syndrome. All four bypasses were patent at the time of angiography one week postoperatively. All four patients were relieved of symptoms of vertebrobasilar insufficiency.

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