Biomedical subjects

R B Dewey

Publications and source records attributed to R B Dewey.

21 records · Page 2Linked to original sources

PubMed1994

Isolated eyelid-opening apraxia: report of a new levodopa-responsive syndrome.

Eyelid-opening apraxia (or involuntary levator inhibition) has been described chiefly in the context of basal ganglia disease. We present two novel cases in which apraxia of eyelid opening developed in the absence of any other CNS signs, and which resolved following treatment with levodopa. We suggest that when inability to open the eyes occurs without associated motor impairment, "apraxia" is the correct descriptive term, and a trial of levodopa should be considered.

Adolescent↗

PubMed1989

Hemiballism-hemichorea. Clinical and pharmacologic findings in 21 patients.

In this series of 21 patients with hemiballism-hemichorea we found an identifiable cause in all. Unlike most other studies in which stroke was the most important cause of the movement disorder, in almost half (10 of 21) of our patients some other cause was found. Hemiballism-hemichorea was often the presenting feature of underlying medical disease. Besides the subthalamic nucleus, other subcortical structures may be involved in the pathogenesis of this hemihyperkinesia. While the movement disorder often improves spontaneously or with pharmacologic therapy, the underlying disease may result in serious consequences.

Adult↗

PubMed1989

The effects of lithogenic bile on gallbladder epithelium.

Prairie dogs were fed a 1.2% cholesterol diet for up to 24 weeks to evaluate the effects of lithogenic bile on the mucosa of the gallbladder. There was a progressive increase in the lithogenic index of the gallbladder bile (1.44 +/- 0.15 at 4 weeks, p less than 0.05). Fifty-five of 70 animals developed gallstones between the second and fourth week. Increasing stone burden was associated with a 27% (p less than 0.05) decrease in the electrical resistance of the epithelium and a 60% (p less than 0.05) decrease in net sodium transport when measured isotopically in an Ussing chamber (3 weeks). After 4 months, seven of ten animals developed inflammatory mucosal polyps characterized by a heavy infiltration of plasma cells into an expanded matrix. Cellular infiltration began as early as 2 weeks. These changes occurred without alterations in the ultrastructural appearance of the epithelium.

Absorption↗