Biomedical subjects

R B Duthie

Publications and source records attributed to R B Duthie.

12 recordsLinked to original sources

PubMed1992

Bone resorption by cells isolated from rheumatoid synovium.

Cellular mechanisms accounting for the osteolysis of rheumatoid erosions are poorly understood. Cells were isolated and characterised from the synovium of 16 patients with rheumatoid arthritis (RA) and four patients with osteoarthritis and their ability to resorb bone was assessed using a scanning electron microscope bone resorption assay. Macrophages were the major cell type isolated from the synovium of patients with RA. These produced extensive roughening of the bone surface without resorption pit formation. This low grade type of bone resorption was not affected by systemic (calcitonin, parathyroid hormone, 1,25-dihydroxyvitamin D3) or local (interleukin 1, prostaglandin E2) factors influencing bone resorption. Macrophage mediated bone resorption differs qualitatively and quantitatively from that of osteoclasts but is likely to play an important part in the development of marginal erosions in RA.

Adult↗

PubMed1991

Peripheral nerve lesions in hemophilia.

Between 1962 and 1986, eighty-one of the 1351 admissions of patients who had hemophilia to the Nuffield Orthopaedic Centre were for peripheral nerve lesions. Eighty-eight such lesions were identified in fifty-four patients, and thirty-nine of these patients (sixty-one lesions) had adequate follow-up (mean, 8.4 years; range, four months to eighteen years). The femoral nerve was most commonly involved, but involvement of other peripheral nerves also occurred. In thirty (49 per cent) of the sixty-one lesions, the nerve had full motor and sensory recovery; in twenty-one (34 per cent), a residual sensory deficit; and in ten (16 per cent), both a persistent motor and sensory deficit. Patients who had antibodies to factor VIII were significantly less likely to recover full motor or sensory function than were those who did not have such antibodies, and the time to full motor recovery in these patients was significantly longer.

Adolescent↗

PubMed1979

Differentiating methadone outpatients from psychiatric outpatients and normals with the Mini-Mult.

Investigated whether the Mini-Mult could differentiate outpatient heroin addicts from outpatient psychiatric and normal populations. A multiple discriminant analysis was done with 30 Ss that compared the three groups across the 11 Mini-Mult scales. Significant results were obtained at the .05 level for the following scales: L, F, 1, 2, 3, 4.

Heroin Dependence↗

PubMed1979

Orthopaedic undergraduate education.

Musculoskeletal disease in the community is common, and much of it responds to early diagnosis and preventive care. At the same time, modern orthopaedics, like so many specialist subjects, has increased significantly in depth and detail pari passu with its advances. It therefore becomes all the more important in desiging undergraduate teaching programmes in these specialist subjects to provide a comprehensive basic training programme that is flexible enough to move with the specialty. The orthopaedic undergraduate education programme in Oxford meets these requirements, embraces all aspects of the subject, and enables the medical student to examine the musculoskeletal system with confidence to interpret his findings, without making him an embryo specialist.

Audiovisual Aids↗

PubMed1979

Pearson and the patient.

This lecture covers some subjects of direct concern to the medical profession contained within the Pearson Report. Each injury group was examined by the Royal Commission, both here and abroad, particular attention being paid to the relationship between tort and social security. By consensus it was proposed that in the majority of fields no-fault compensations should be extended but that the tort system should continue to have a role. Recommendations were also put forward that no damages should be permitted for non-pecuniary loss during the first 3 months and that the full value of the social security benefits should be deductible from all tort damages. Damages for permanent injury or death should be index-linked periodic payments. A new no-fault compensation scheme for road accidents was described as well as a new disabled children's allowance of 4 pounds per week with a mobility allowance at the lower age of 2 years. Medical injury was examined carefully, but it was decided that negligence liability should continue unchanged, with the proviso that the no-fault compensation schemes in New Zealand and in Sweden should be followed. These two schemes have therefore been described in some detail.

Child↗

PubMed1979