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Biomedical subjects

R B Erichson

Publications and source records attributed to R B Erichson.

8 recordsLinked to original sources
PubMed1982

Effect of drug-induced platelet dysfunction on surgical bleeding.

Two hundred patients scheduled to undergo a variety of surgical and gynecologic procedures were studied to determine whether increased surgical bleeding occurred in those who had drug-induced platelet dysfunction. Twelve of 55 patients (22 percent) who had a positive drug history and abnormal platelet aggregation were judged to have excessive bleeding at surgery or postoperatively, compared with 7 of 97 patients (7 percent) with a negative drug history and normal platelet aggregation (p less than 0.02). The data suggest that drug-induced qualitative platelet dysfunction predisposes to excessive surgical bleeding.

Blood Coagulation Tests↗
PubMed1982

Multiple myeloma protein with three light chains.

A case of immunoglobulin G (kappa) myeloma showed, in addition to the monoclonal IgG(kappa) arc, two kappa chains in the serum. The urine specimen contained 7.75 g of kappa chains per liter. The electrophoretically fast-moving kappa chain in serum was shown by immunoelectrophoresis and Ouchterlony immunodiffusion to be a complex of kappa chains and alpha 1-antitrypsin. This complex, which was detected only transiently in the patient's blood, was composed of a monomeric kappa chain bound to the antitrypsin by a disulfide bond. The predisposing factor for the formation of this complex is unclear, but patients showing this complex usually have kappa type myeloma protein and excrete kappa chain in urine at more than 1 g/L. The relationship between chemotherapy and formation of the kappa chain-antitrypsin complex needs further investigation.

Blood Protein Electrophoresis↗