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Biomedical subjects

R B Gudkova

Publications and source records attributed to R B Gudkova.

8 recordsLinked to original sources
PubMed1992

[Gluten enteropathy].

The authors relate the results of 10 years of observations of 113 patients suffering from gluten enteropathy (GE) of the adults. In all the patients, the diagnosis was supported by the presence of hyper-regenerative atrophy of the small intestinal mucosa (total in 70% and subtotal in 30%). Metabolic disorders and cellular immunity were investigated. At the onset of the observations 70.7% of the patients demonstrated malabsorption, stage III gravity, and 29.3% stage II. It has been proved that permanent and strict adherence to the agluten diet and administration of corticosteroids in the most severe cases in combination with pathogenetic therapy of diarrhea and metabolic disorders permit attaining a steady clinical remission, improvement of normalization of the biochemical and immunological characteristics, a tendency toward normalization of the small intestinal mucosa, and even the recovery of its normal structure in part of the cases.

Adolescent↗
PubMed1990

[Ultrastructural characteristics of autorosette formation in vivo].

The interaction of extravascular erythrocytes with lymphocytes, macrophages, polymorphonuclear leucocytes and fibroblast like cells in human gastric ulcer and in post-ulcer scar was studied by means of electron microscopy and cytochemical methods. It was shown that such interaction results in autologous rosette formation. There were also autorosette in the capillaries where autorosette forming cells were endothelial cells and lymphocytes. Many kinds of autorosette forming cells were connected with some peculiarities of ulcer process in the stomach.

Chronic Disease↗
PubMed1990

[General variable immunologic deficiency with malabsorption syndrome].

Twenty-two patients with general variable immunodeficiency (GVI) and malabsorption syndrome (MS) were followed up for 2-12 years. III degree MS was found in 17 cases. Serum immunoglobulins concentration and T-lymphocyte count were reduced, the latter at the expense of theophylline-resistant and active E-RFC. With casein and milk albumin as the antigens, lymphokine-producing capacity of the mononuclear cells appeared elevated. MS treatment with adjuvant gamma-globulin produced a positive trend in clinical manifestations of the disease, content of T lymphocytes and relevant subpopulations. Long-term results were less favourable: partial compensation with recurrences persisted in 15 patients only. Seven patients died: two of pneumonia, five of cardiac failure and visceral dystrophy. All MS patients are recommended to undergo serum immunoglobulins diagnosis of GVI and in case of its verification to receive life-time gamma-globulin replacement therapy.

Adolescent↗
PubMed1979

[Analysis of the effect of morphine on the reproductive capacity and immunological status of mice].

Embryogenesis process is disturbed under the action of prolonged morphine administration to CBA mice. Simultaneously a decrease in the level of antibody-synthesizing cells and a significant reduction in the cooperating interaction of T and B lymphocytes in response to the injection of sheep red blood cells are noted. At the same time stimulation of bone marrow cells and specific sensitization of MIF-inducers to the antigen from the brain of morphinized mice are revealed.

Animals↗
PubMed1976

[Enzymatic and immunologic activity of lymphocytes during chemical carcinogenesis].

The activity of acid phosphatase and some dehydrogenases in the peripheral blood lymphocytes was compared with the development of cell immunity, assessed by the macrophage migration inhibition test, during chemical carcinogenesis in Wistar rats. At the early stages of the carcinogenesis the changes of the enzymatic activities of succinic dehydrogenase and acid phosphatase proved to coordinate with a sufficiently high level of the immunological reactivity of the cell type in 66% of the animals. With the progressive growth of the tumours there occurred a disturbance of the enzymatic balance in the lymphoid cells and a simultaneous decrease in the immunological response.

9,10-Dimethyl-1,2-benzanthracene↗