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Biomedical subjects

R B Harrison

Publications and source records attributed to R B Harrison.

At least 19 recordsLinked to original sources

Natural history of bacteriuria in schoolgirls. A long-term case-control study.

To define better the natural history of bacteriuria in females, we followed 60 schoolgirls with bacteriuria and 38 matched controls for periods ranging from nine to 18 years. Among the schoolgirls with bacteriuria (greater than or equal to 10(5) organisms per milliliter in two or more consecutive cultures), reflux was repaired in five, nephrectomy was performed in two, and reduced inulin clearance was noted in one subject with atrophic pyelonephritis. Serum creatinine was slightly higher in cases than in controls. Renal scars or caliectasis occurred in 16 cases but in none of the controls. Blood pressure was similar in both groups. Episodes of bacteriuria in cases and controls were, respectively: five or more episodes, 21.7 and 2.6 per cent; and episodes during pregnancy, 63.8 and 26.7 per cent. Seven children of the cases but none of the children of controls showed urinary-tract infections. Bacteriuria among schoolgirls defines a group at great risk of recurrent symptomatic infections and renal scars and at low risk of reduced renal function.

Acute Disease

Hypertrophy of the talar beak.

Hypertrophy of the talar beak is the product of traction of the insertion of the joint capsule. It is commonly seen in athletes and may be entirely asymptomatic despite its size. It should not be mistaken for spurring of the articular margin of the talus which is seen in tarsal coalition.

Bone Diseases

Gas in the appendix: a sometimes significant but nonspecific diagnostic sign.

The gas-filled appendix is an uncommon roentgenographic sign that has been considered to be virtually diagnostic of acute appendicitis when the appendix is positioned caudad to the cecum in the right lower quadrant of the abdomen. Three patients had gas in the appendix in the absence of acute appendicitis. This diagnostic sign is therefore not specific for appendicitis. Regardless of its location, the appendix may contain gas despite the absence of intrinsic disease.

Acute Disease

Subtle obstructive uropathy resulting from encasement of the ureters by tumor.

The diagnosis of obstructive uropathy may be difficult in the occasional case in which there is little or no dilatation of the collecting system. A case is presented in which anuric renal failure resulted from encasement of the ureters by tumor. The excretory urogram revealed a delayed pyelogram and a dense nephrogram with minimal dilatation of the collecting systems. The combination of a dense nephrogram and delayed pyelogram should raise the possibility of obstruction, regardless of the appearance of the collecting systems.

Anuria

Peritendinitis calcarea of flexor carpi ulnaris.

Calcific tendinitis of the flexor carpi ulnaris presents a characteristic radiographic appearance of amorphous calcification near the pisiform. This calcification frequently is associated with acute symptoms and may be related to certain occupations and hobbies. Knowledge of the pertinent anatomic and radiographic criteria permits accurate diagnosis.

Calcinosis

Stratification in the gallbladder during intravenous cholangiography.

The stratification (layering) phenomenon in the gallbladder is a source of errors in interpretation of intravenous cholangiography. It may mimic stones that do not exist or conceal stones that do. To avoid false-positive or false-negative interpretations, it is suggested that delayed films be taken at 4 hours in cases which demonstrate a layering phenomenon. By this time, a normal gallbladder will be homogeneously opacified and a diseased one will reveal its stones. Horizontal beam roentgenograms are mandatory for complete evaluation.

Adult

Gray scale ultrasonography in the evaluation of hydrocephalus and associated abnormalities in infants.

Improved gray scale ultrasonic equipment has made two-dimensional echoencephalography a useful diagnostic tool in the examination of the infant brain for fluid-containing structures such as dilated ventricles and cysts. Eighteen infants have been examined to exclude hydrocephalus and other abnormalities. Ten had significantly dilated lateral ventricles and three of these were shown to have associated intracerebral abnormalities. Another infant was demonstrated to have an arachnoid cyst or subdural hygroma with normal size ventricles. Ten of the 11 abnormalities were confirmed by some other neuroradiologic study.

Brain

Diffuse cortical calcification in rejected renal transplants.

Two cases of diffuse cortical calcification in rejected renal transplants are presented. Rejected renal transplants are added to bilateral renal cortical necrosis and chronic glomerulonephritis as causes of diffuse cortical calcification. Possible mechanisms of calcification are briefly discussed.

Adult

Cerebrospinal fluid ascites.

One new and one previously reported case of cerebrospinal fluid ascites following ventricular-peritoneal shungting are presented. Ultrasonic investigation is now most helpful.

Ascites

Radiographic findings in Wolman's disease.

A case of Wolman's disease or primary familial xanthomatosis with calcification of the adrenals is presented. The bilaterally enlarged, calcified adrenals are virtually pathognomonic of this condition.

Adrenal Gland Diseases

Charcot's joint: two new observations.

The pattern of soft tissue calcification in the three cases presented suggests that the debris about a Charcot's joint may break out of the periarticular space and dissect along muscle planes. Follow-up films of one of the cases documents that such calcifications may be resorbed. The reason for selective involvement of certain muscle groups is obscure. To my knowledge, these observations have not been reported previously.

Arthropathy, Neurogenic

A solitary calyx in a human kidney.

A solitary kidney containing a single calyx and probably a single papilla is described. The embryology of this entity and its similarity to the unipapillary kidney in other mammals are discussed.

Female