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Biomedical subjects

R B Kurashvili

Publications and source records attributed to R B Kurashvili.

At least 19 recordsLinked to original sources
PubMed2006

[Characteristic changes of skin and its accessories in type 2 diabetes mellitus].

The different changes are seen on skin and it's accessories in Diabetes Mellitus, some of which represent the prognostic indicator of complicated diabetes and some directly contribute in development of them. Numerous problems concerned with the diabetic foot could be avoided due to early detection and treatment of these changes. The objective data on foot examination of 195 patient with Type 2 Diabetes Mellitus were analyzed considering the grade of severity of Diabetic Peripheral Neuropathy (DPN). It was revealed that the skin humidity is dependent on DPN, particularly, the DPN 2-4 times raises the dryness of the skin on the foot; the risk of callus development is significantly high in case of painless and complicated DPN, accordingly, the possibility of neuropathy ulcer is also high in this group. The high incidence of onychomycosis and Yellow nails syndrome was noted, accordingly in 28.7% and 39.4% of cases; the Melin's shin spots were found in fourth of the patients, mainly in men; a few cases of rubeosis plantarum and bulbosis diabeticorum were revealed; the cases of necrobiosis were not noted. Thus, the prevalence of the characteristic changes of skin and it's accessories in Type 2 Diabetes Mellitus is sufficiently high and it depends on the severity of DPN, using early detection of them may avoid many problems related to diabetic foot and its complications.

Dermatomycoses↗
PubMed1991

[Rationale for using kinin system inhibitors in patients with acute ischemia and infarction of the myocardium during the prehospital phase].

The paper discusses if it is advisable to use kallikrein-kinin system inhibitors earlier. A total of 122 patients with acute ischemia and infarction of the myocardium were studied. Contrykal and heparin infused in the prehospital period, followed by hospital treatment are optimal to prevent vascular wall lesions, maximally retain retrograde blood flow, and substantially reduce the size of myocardial infarction. Therapy with protease inhibitors proved to be most beneficial within the first 2 hours of the disease, as evidenced by a profound improvement in the clinical course of myocardial infarction, a decrease in ECG and precordial mapping signs of ischemia, a positive change in myoglobin and MB creatine phosphokinase levels, and a significant reduction in the rehabilitative period.

Adult↗
PubMed1989

[Clinical course and the effectiveness of conservative treatment of prolactin-secreting pituitary adenoma].

Forty-eight women with prolactin-secreting adenomas of the hypophysis and 22 patients with suspected microadenomas, aged 16 to 38, were examined. The highest blood prolactin levels and the most manifest symptoms were revealed in the patients with x-ray evidence of hypophyseal macroadenoma. Prolactin levels were lower, though still elevated, in the cases with small adenomas. In the cases with high prolactin levels but without x-ray signs of hypophyseal adenoma the clinical symptoms were less manifest. LH concentrations were significantly reduced in all the patients. Seven patients in whom parlodel therapy was ineffective were operated on. In the rest parlodel therapy, carried out for 1-2 years, was conducive to stabilization of the tumor process, despite a recurrence of hyperprolactinemia.

Adenoma↗
PubMed1986

[Control and correction of the blood sugar in diabetes with concomitant ischemic heart disease using the artificial beta-cell apparatus employing glucose oxidase as the enzyme].

The apparatus "Artificial Beta-Cell" or "Biostator" was used in treatment of 115 patients with diabetes mellitus and concomitant ischemia of the heart. At the same time 30 patients with diabetes mellitus and ischemia of the heart were treated for diabetes mellitus with the routine methods. Hormones such as ACTH, STH, hydrocortisone, immunoreactive insulin and S-peptide, lipid metabolism and glycosylated hemoglobin were investigated in the time course of the treatment. It was shown that adequate correction of glycemia with the "Biostator" promoted renormalization of the levels of ACTH and hydrocortisone. The results were especially favourable in the group of patients with myocardial infarction and chronic ischemia of the heart with the signs of cardiac insufficiency. Moreover, in the patients of the main group there was a tendency for normalization of lipid metabolism and glycosylated hemoglobin. The results of carbohydrate metabolism compensation in patients of the control group were not always satisfactory and the periods of compensation were longer. The clinico-biochemical indices reflected the favourable effect of the use of the "Biostator" and its advantages over the routine methods in treatment of diabetes mellitus.

Blood Glucose↗
PubMed1985

[Effect of 24-hour intravenous administration of nitroglycerin on the status of the focus of a lesion in patients with an acute myocardial infarct].

Nitroglycerin was drip-infused for 24 hours to 35 patients with acute myocardial infarction. Thirty-three patients were taken as controls. Intergroup comparisons were made of the patterns of precordial cartograms from 35 leads and serial measurements of plasma MB CPK activity. The treatment was shown to reduce significantly the activity of MB CPK and total ST elevation, the effect being particularly pronounced with the drug administered within the first 6 hours of the attack. It was also shown that 24-hour intravenous nitroglycerin infusion produced a significant decrease in the end diastolic pressure of the pulmonary artery that occurred by the 15th minute and persisted till the end of the administration.

Acute Disease↗
PubMed1985

[Hypermyoglobinemia and creatine phosphokinase MB activity as signs of combined myocardial lesion and acute cerebral circulatory disorder].

In order to detect simultaneous damage to the myocardium in cerebral stroke the authors radioimmunoassayed myoglubin and activity of the heart fraction of creatine phosphokinase MB (CP K MB) in the blood serum of 22 patients. Hypermyoglobinemia and elevated activity of CP K MB were revealed in almost all cases of hemorrhagic stroke (15 patients) whereas in patients with ischemic stroke they were identified far less frequently. Thus, hypermyoglobinemia and the activity of CP K MB correlate with the macro- and microscopic picture of myocardial damage and may serve as its diagnostic criteria when both the clinical picture and ECG findings prove uninformative.

Adult↗
PubMed1984

[Computer analysis of the ECG during physical exercise].

Treadmill tests were performed in one hundred men below 60, with computerized assessment of their ECG data. Reduced R wave amplitude from lead V5 at maximum exercise was only noted in subjects showing no electrocardiographic evidence of ischemia. Increased R wave from lead V5 was regarded as cardiac dysfunction in response to exercise, which, in the presence of ischemic ECG changes, preceded the development of pathologic ST depression. A negative T wave from leads III and aVF on resting ECG did not correlate with abnormal exercise test results. Ventricular arrhythmias were more common in subjects with non-ischemic ECG changes during exercise.

Adult↗
PubMed1983

[Hemodynamic shifts in patients with congestive heart failure during treatment with sodium nitroprusside].

Hemodynamic effects of sodium nitroprussid were studied in 21 patients with congestive heart failure. Nitroprussid reduced systemic arterial pressure, pulmonary artery pressure, pulmonary capillary wedge pressure, systemic and pulmonary vascular resistance, and increased cardiac index and left-ventricular stroke performance index, thus reducing the pre- and post-load of the left ventricle and improving its functional capacity.

Aged↗