Biomedical subjects
R B Lewis
Publications and source records attributed to R B Lewis.
Identification of the herpes simplex virus DNA polymerase gene.
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An improved blood-loss monitor.
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Anaesthesia for laryngoscopy: a new method of ventilation.
A technique for anaesthesia for laryngoscopy using a Foley catheter is described.
Use of 1-H nuclear magnetic resonance spectroscopy for sequence and configuration analysis of cyclic tetrapeptides. The structure of Tentoxin-1,2a--d.
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Connective tissue activation. X. Current studies of the process and its mediators.
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The amino acid sequence and configuration of tentoxin.
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A modification of Cobb's suction union to allow controlled ventilation during fiber-optic bronchoscopy.
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Influence of acetylsalicylic acid, an inhibitor of prostaglandin synthesis, on the duration of human gestation and labour.
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Contact mattress to prevent heat loss in neonatal and paediatric surgery.
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Frequency of neoplasia in systemic lupus erythematosus and rheumatoid arthritis.
A patient population admitted to the hospital for either SLE or RA was surveyed for the subsequent development of neoplasms. The frequency of neoplasm in SLE patients appeared to be exaggerated, whereas the frequency of subsequent neoplasm in rheumatoid patients was unexpectedly low. A paucity of nephritis in the SLE group was noted. Further reports are encouraged so that the magnitude of the risk of malignancy developing with immunosuppressive therapy can be more precisely ascertained.
Assessment of the presence of cytomegalovirus-neutralizing antibody by a plaque-reduction assay.
Evaluation of the in vitro neutralizing activity of 30 immunoglobulin G (IgG) preparations and seven batches of pooled plasma against human cytomegalovirus (CMV) was performed by plaque-reduction assays. There were definite differences detected by these methods that could permit the selection of preparations with highest titers for clinical trials. The addition of guinea pig complement to the plaque-reduction assay enhanced inhibition of CMV; thus, guinea pig complement should be used in assays of IgG preparations. There was no relationship between the ELISA-derived optical density values of the IgG samples and the titers determined by plaque neutralization. These data suggest that the results of plaque-reduction neutralization assays provide important information about preparations of antibody that may be selected for patient administration. The preparations selected for their high titers by neutralization assays differ significantly from those identified by another method.
Educational services for children with chronic illnesses: perspectives of educators and families.
Two parallel studies examined schools' and families' perceptions of the needs of children with chronic illnesses. Samples of 80 California school districts and 72 families were interviewed regarding types of chronic illnesses and school services, perceptions of and barriers to services, strategies for overcoming barriers, and fears and concerns of children with chronic illnesses. Most students were served in regular classes or at home. The most common barriers named by districts were funding and lack of public and staff awareness. Barriers named by families included teachers' misunderstanding of the child's needs and misinformation about the illness. Families focused on social-emotional issues and the impact of illness on their child's life; districts emphasized school absences and falling behind in schoolwork.
The university and federal dollars.
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Assistive technology and learning disabilities: today's realities and tomorrow's promises.
Many forms of technology, both "high" and "low," can help individuals with learning disabilities capitalize on their strengths and bypass, or compensate for, their disabilities. This article surveys the current status of assistive technology for this population and reflects on future promises and potential problems. In addition, a model is presented for conceptualizing assistive technology in terms of the types of barriers it helps persons with disabilities to surmount. Several current technologies are described and the research supporting their effectiveness reviewed: word processing, computer-based instruction in reading and other academic areas, interactive videodisc interventions for math, and technologies for daily life. In conclusion, three themes related to the future success of assistive technology applications are discussed: equity of access to technology; ease of technology, use; and emergent technologies, such as virtual reality.
Characteristics of rheumatoid arthritis in a male population.
A population of males and females with definite or classical rheumatoid arthritis was studied. The males seem to have more severe disease with positive latex fixation, radiographic changes and rheumatoid nodules than is reported in the literature and the female comparison population. This difference can probably be explained because most studies have a female preponderance and our experience suggests that the disease is more severe in males.