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Biomedical subjects

R B Minderaa

Publications and source records attributed to R B Minderaa.

40 records · Page 3Linked to original sources

Platelet imipramine binding in autistic subjects.

Previous reports of elevated platelet serotonin (5-HT) concentrations in autistic subjects suggest that platelet 5-HT uptake might be altered in autism. Parameters of 3H-imipramine (IMI) binding were measured in 11 drug-free autistic subjects and 10 normal volunteers. Similar means (+/- SD) for Bmax (autistics, 1350 +/- fmole/mg protein; normals, 1590 +/- 206 fmole/mg protein) and Kd (autistics, 0.98 +/- 0.10 nM; normals, 0.94 +/- 0.13 nM) were found in the two groups. The normal number (Bmax) and affinity (Kd) of the IMI binding site in autistic subjects suggest that the regulation of 5-HT uptake is not different in autism.

Adolescent↗

Behaviour therapy of obese children and results 21 months after treatment.

Two groups of pre-pubescent obese children were given modified behaviour therapy. A shaping procedure was used to bring about changes in quantity and quality of food eaten, physical activities, and eating behaviour. In addition, attempts were made to get the children to distinguish better between hunger and satiation and to improve the interactions between children and parents. The children were trained to effect desired behavioural changes themselves on the basis of their own observations. Four of the 11 children displayed a substantial weight reduction which was maintained in follow-up. In the case of the other children it appeared that psychopathological and constitutional factors prevented them from making use of the strategy offered.

Adolescent↗