CUTANEOUS REACTIONS TO ANTIBIOTICS.
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Biomedical subjects
Publications and source records attributed to R B REES.
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This article deals with a number of newer drugs now being employed in dermatology. The great beneficial role of corticoids both topically and systematically for various inflammatory dermatoses is now amply proved. The addition of a corticoid to a conventional acne lotion renders it much more effective. Nystatin for monilial infections is especially effective in a powder form. For systemic use Griseovulvin, now becoming available, is the most interesting current development in dermatology. Presumably, it is highly effective against ringworm of the hair, nails and skin. The role of synthetic antimalarials in treating chronic discoid lupus erythematosus and light sensitivity eruptions also is firmly established.
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Thirty cases of anogenital moniliasis were studied. Only five followed oral use of broad spectrum antibiotics. Although anogenital pruritus commonly follows the use of such drugs, it is rarely proved to be moniliasis, which is clinically diagnosed by symptoms of intertriginous denudation with satellite vesicopustules or the presence of cheesy, grossly detachable plaques. The diagnosis may be confirmed by microscopic observation of delicate hyphae and clusters of spores, or of chlamydospores on corn meal agar. One per cent aqueous gentian violet, 0.1 per cent gentian violet jel, or locally applied mercurials are the most effective forms of treatment, but effort must also be directed against predisposing factors (obesity, hyperhidrosis, oral or local use of broad spectrum antibiotics, diabetes and pregnancy).
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