PubMed Health⌕ Search

Biomedical subjects

R B Resnick

Publications and source records attributed to R B Resnick.

At least 37 records · Page 2Linked to original sources
PubMed1982

Outpatient opiate detoxification with clonidine.

The finding that clonidine has significant withdrawal-suppressing effects in opiate addicts has led to clinical testing of its utility as a non-opiate treatment for opiate detoxification. Our outpatient studies have shown that clonidine can be used safely and effectively to detoxify opiate-dependent patients without hospitalization. Because of sedative and hypotensive side effects as well as varying sensitivity to the drug, clonidine doses must be individualized according to each patient's blood pressure and symptoms. Clonidine seems best suited for clinical use as a transitional treatment between opiate dependence and naltrexone. Our 10-day outpatient clonidine detoxification procedure has been extremely effective in allowing patients abruptly to discontinue the use of opiates and stay opiate-free long enough to initiate naltrexone treatment. Clonidine's side effects of sedation and hypotension have limited its clinical usefulness, particularly with outpatients, suggesting that other alpha-2 noradrenergic agonists might be found to have similar antiwithdrawal efficacy but without clonidine's undesirable side effects. Initial outpatient testing of lofexidine, a structural analog of clonidine, indicates that this drug may be as effective as clonidine for opiate detoxification and might be more suitable for outpatient treatment if it is found to lack the sedative and hypotensive side effects sometimes found with clonidine.

Ambulatory Care↗
PubMed1977

Acute systemic effects of cocaine in man: a controlled study by intranasal and intravenous routes.

Nineteen healthy volunteer subjects who regularly administered cocaine to themselves were given placebo and 10 and 25 milligrams of cocaine hydrochloride intravenously and intranasally. A dose of 100 milligrams of cocaine was administered only by the intranasal route. By this route 10 milligrams of cocaine produced no changes different from placebo, and 25 milligrams of cocaine produced physiologic changes only in systolic blood pressure. The 100-milligram dose given intranasally and all of the doses given intravenously produced significant dose-related physiologic and subjective responses.

Administration, Intranasal↗
PubMed1977

Naloxone-precipitated withdrawal: a method for rapid induction onto naltrexone.

We examined naloxone-precipitated withdrawal as a means for rapid opiate detoxification and induction onto naltrexone. In 29 patients dependent on methadone (5 to 20 mg/day), abstinence was precipitated by an injection of naloxone. Repeated injections of naloxone were given subsequently until symptoms of abstinence were no longer induced. Successive injections induced less intense withdrawal assessed by vital signs and ratings on abstinence scales. The most rapid procedure consisted of 1.2 mg naxolone every 30 min for 3 to 6 hr, for 3 to 6 hr, followed by hourly increasing doses of naltrexone. This procedure allowed transition from opiate dependence to naltrexone maintenance (50 to 100 mg/day) within 48 hr. The results are consistent with assumptions that antagonists actively displace opiates from receptor sites.

Adult↗