PubMed Health⌕ Search

Biomedical subjects

R B Strelkov

Publications and source records attributed to R B Strelkov.

At least 19 recordsLinked to original sources
PubMed1985

[Increased body resistance to the toxic action of cyclophosphane through the use of short-term hypoxic hypoxia].

Experiments were carried out on 535 SHK albino male mice weighing 24.0 +/- 4.0 g to study the modifying effect of gas hypoxic mixture containing 10.0 +/- 1.0% O2 and 90.0 +/- 1.0% N2 (GHM-10) on cyclophosphane toxicity after intraperitoneal injection of 800, 1000, 1200, 1400, 1600, 1800, and 2000 mg/kg. Before the injection, the animals were kept in a hypoxic medium for 30 min, which reduced mortality rate. It is found that human organism can endure GHM-10 quite well.

Animals↗
PubMed1985

[The immediate and late results of protecting the patient's normal tissues by using the gas hypoxic mixture GHM-10 in the radiation therapy of breast cancer].

The effect of inhalation of gaseous hypoxic mixture GHM-10 (oxygen--10 +/- 1.0 and nitrogen--90.0 +/- 1.0%) on radiation response of normal tissues was studied in 184 breast cancer patients. The mixture was administered to 120 patients while 74 controls received a standard course of radiotherapy. Administration of the mixture improved normal tissue resistance to radiotherapy for breast cancer and was followed by lower incidence of long-term radiation injury, lower frequency and shorter duration of general vegetative reactions to radiation.

Adult↗
PubMed1984

[Effect of whole-body irradiation of females on pregnancy and postnatal development of the offspring].

In 218 primigravida rats of Wistar strain with body mass 200-250 g radiosensitivity during the whole period of pregnancy has been studied after a single total gamma-radiation with 60Co given in LD50 2.0 Gy. The multifactor analysis includes: dynamics of the body mass of the pregnant rats, ability to implantation and pregnancy, duration of pregnancy, number of births that failed, body mass loss during delivery, death of the embryos during the antenatal period, number of viable offsprings, dynamics of body mass in the offsprings and their viability during 30 days after birth, time for covering with fur and eyes opening, developmental anomalies etc. Quantitative and qualitative postradiative disorders of the intrauterine and postnatal development of the offsprings are described. The most sensitive days of pregnancy are revealed (the 1st--3d and the 9th--11th days).

Abnormalities, Radiation-Induced↗
PubMed1981

[Biorhythm of oxygen tension in uterine and fetal tissues].

Hypoxic cycles with a two fold reduction in PO2 levels (down to 51.7, 43.9 and 53.4%), the frequency of 0.63 +/- 0.07, 1.47 +/- 0.14, 1.98 +/- 0.3 per minute, and the duration of 45.4 +/ 2.9, 28.4 +/- 2.3 and 19.8 +/- 1.9 sec., respectively, were recorded during the measurement of oxygen content in the uterine tissue of pregnant (3-5 days) and non-pregnant rats, as well as in tissues of 13-14-day-old rat fetuses. The oxygen content remained unchanged throughout the whole experiment (30 min) in the peristaltic intestinal wall. The hypoxic cycles were assessed as a mechanism of rhythmic periodic stimulation of metabolic reactions directed towards not only the increased resistance to hypoxia but also towards non-specific resistance of uterine fetal tissues and female body in and out of pregnancy.

Animals↗
PubMed1979

[Radiation protection using a gaseous hypoxic mixture in oncological practice].

Studies on volunteers have shown that the gas hypoxic mixture containing 10% of oxygen and 90% of nitrogen (GHM-10) renders a protective action on the genetic apparatus of human skin cells but provides no protection of the peripheral blood leucocytes, which show the identical character of metabolic processes as neoplastic cells. Under clinically performed distant x-ray therapy for breast cancer the inhaling of GHM-10 was found to render the antiradiation protective action on different normal tissues (skin, subcellular connective tissue, muscle tissue, mammary gland tissue), but it fails to protect the tumor tissue and regional lymph nodes involved. The clinical observations were supported by pathomorphological examination of the operation material.

Adult↗
PubMed1978

[Subcellular reaction to cerebral hypoxia].

Compensatory-adaptive reaction of the brain to hypoxia depends on destructive and reparative processes developing in neuronal and glial elements. A drastic tension and reconstruction of the energy apparatus--mitochondria occurs, as well as reversible disturbances in informative connections between the nucleus and cytoplasm and between nerve fibers and synapses. As a result, structural-functional activity of organells decreases along with changes in metabolic processes. Destructive processes in oligodendroglia, at all stages of the experiment, are more pronounced than in neurons. Preliminary injection of hydroxybutyric acid to the animals preserves the cellular energy potential under hypoxia, that is evident from the lack of severe alterations in mitochondria and other organells. Mechanisms of the adaptive-compensatory reaction in cortical neurons under hypoxia are connected with tension and reconstruction of all organells of the brain cellular elements and with biochemical shifts of lactate dehydrogenase enzymes.

Adenosine Triphosphatases↗
PubMed1978

[Protective effect of sodium hydroxybutyrate and mexamine on the body and cerebral cortex neurons during hypoxia].

Experiments on white non-pure male mice have established that NA oxybutirate in doses 100 mg/kg and mexamine in doses 2.5 mg/kg possess antihypoxic properties in conditions of severe hypoxia corresponding to a height of 10 000 m. In a combined introduction of Na oxybutirate and mexamine in the above-mentioned doses there is an increase of their antihypoxic action. It was demonstrated that Na oxybutirate, mexamine and their combination exposes a distinct protective effect on the cortical neurons on rats in conditions of hypoxia. It is assumed that the protective action of the studied antihypoxants on the cortical neurons is realized with the aid of the same mechanisms as in a physiological adaptation to hypoxia.

5-Methoxytryptamine↗