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Biomedical subjects

R B van Leeuwen

Publications and source records attributed to R B van Leeuwen.

7 recordsLinked to original sources
PubMed1995

Cardiac arrest following an iatrogenic 3,4-diaminopyridine intoxication in a patient with Lambert-Eaton myasthenic syndrome.

Syndromes with impaired neuromuscular transmission are frequently treated with pyridine derivates. 3,4-diaminopyridine is thought to have fewer side effects than the commonly used, but less potent, 4-aminopyridine. We describe a patient with an initially unrecognized iatrogenic intoxication with 3,4-diaminopyridine. Except for a life threatening arrhythmia, symptoms were similar to a 4-aminopyridine intoxication. The patient made a full recovery with symptomatic treatment and withdrawal of the drug.

4-Aminopyridine↗
PubMed1992

Chemonucleolysis. Predictive factors.

The aim of this study was to identify factors in the patient's history and parameters of the neurologic, roentgenographic, and electromyographic examinations as well as cerebrospinal fluid analysis before chemonucleolysis that might be used to predict the results of this treatment after 1 year. On the basis of a combination of three factors, that is, the presence or absence of a narrowed intervertebral space on the lumbosacral survey film, the localization of the disc herniation (medial, mediolateral or lateral) on the computerized tomographic scan and the number of cells in the cerebrospinal fluid, a satisfactory result could be predicted for 92% of the patients.

Adult↗
PubMed1991

CT examination of 91 patients after chemonucleolysis.

Ninety-one patients underwent a repeat CT examination 2-3 months after chemonucleolysis. In 39 patients the size of the herniation was unchanged; no correlation could be found between the CT examination and the clinical results. One year after chemonucleolysis, 27 of the patients underwent a third CT examination. The majority of the scans revealed a reduction of the herniation, while 16 of the patients still had a hernia. No correlation could be found between the clinical results and the CT examination. We conclude that a repeat CT examination after chemonucleolysis does not permit evaluation of patients with persistent or recurrent radicular pain.

Adult↗