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Biomedical subjects

R Bütler

Publications and source records attributed to R Bütler.

At least 55 records · Page 3Linked to original sources

[Prevention of the post-transfusion hepatitis].

For prophylaxis of posttransfusion hepatitis three procedures can be considered: 1. recognition of "infectious" blood donors, 2. elimination of the infectious agent from the blood units (or blood derivatives), 3. protection of the recipient by immunophrophylaxis. Among all available methods screening of blood donors for hepatitis B antigen (HB-sAg) by a sensitive test (e.g. radioimmunoassay or reversed passive hemagglutination) is presently the most efficient. Despite this precaution it can be estimated that three to four cases of overt posttransfusion hepatitis will still occur in 1000 transfusions in this country. A number of these might be due to agents other than hepatitis B virus, but another proportion may also be attributed to non-transfusion-induced infection originating from the hospital environment. Efforts are required to reduce this source of infection.

Antibody Formation↗

Autoantibodies with antilipoprotein specificity and hypolipoproteinemia in patients with cancer.

Sera from 151 patients with a variety of cancers were screened for antibody-like activity against lipoproteins. Eighteen % of the sera exhibited activity against autologous and homologous high-density lipoproteins and 3% exhibited activity autologous and homologous low-density lipoprotiens. Antibody-like binding was proven by its restriction to the Fab fragment of IgG. The reactive part of the lipoprotein molecule was shown to be the appoprotein. Quantiation of the serum lipoproteins indicated that thehigh-density lipoprotien concentration in the sera of cancer patients was significantly lower (psmaller than 0.01) when antibody was present. These observation suggest that autoimmune mechanisms may be responsible for the decreased high-density lipoprotein serum levels in some patients with cancer.

Antigen-Antibody Reactions↗