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Biomedical subjects

R Bachvaroff

Publications and source records attributed to R Bachvaroff.

At least 19 recordsLinked to original sources
PubMed1987

Immune responses to dialyzer contents by dialysis patients.

Serum antibodies to the contents of cuprophan hollow-fiber dialyzers were demonstrated by immunodiffusion in 36 of 68 hemodialysis patients. The antibodies were not absorbed by ethylene oxide or washed cuprophan hollow fibers. No cross-reactivity with Escherichia coli lipopolysaccharide and pneumococcal polysaccharides was noted. The antibodies were IgM and probably IgG. Washed cuprophan hollow fibers did not absorb IgE detected by radioallergosorbent test (RAST). Lymphocyte transformation to the contents of both cuprophan hollow fiber and polyacrylonitrile plate dialyzers was demonstrated. Materials added in manufacture of dialyzers are immunogenic. The long-term biologic effects are unknown.

Antibodies↗
PubMed1984

Scintigraphic evaluation of the viability of cold-preserved kidneys before transplantation.

Renal microcirculation studies utilizing microspheres can provide a highly reliable index of the viability of preserved kidneys. We describe a noninvasive method that permits subsequent transplantation of each tested kidney. Fresh canine kidneys were removed and perfused with either Collins' solution or Collins' solution with 5 mg/l of trifluoperazine (TFP), and preserved at 4 degrees to 6 degrees C in their respective perfusates for 5, 24, 48, or 72 hr. At the end of each period, the preserved kidney was perfused with 50,000 Tc-99m-labeled microspheres. Uniform cortical activity occurred in all kidneys preserved for 5 hr, with moderate decreases in cortical activity at 24 hr. Kidneys perfused with Collins' solution showed progressively decreasing cortical flow with sparse cortical activity after 72 hr. In kidneys perfused with Collins' solution containing TFP, however, cortical flow remained relatively well preserved at 48 and 72 hr. Direct correlation between viability of the cortical microcirculation and the capacity of the corresponding kidney to sustain life upon retransplantation into the original host was observed.

Animals↗
PubMed1975

Histocompatibility studies in a closely bred colony of dogs. V. Mechanisms of cellular adaptation in long-term DL-A identical radiation chimeras.

20 Cooperstown beagles of known DL-A genotypes (B" dogs) were exposed to supralethal total body irradiation and received a bone marrow allograft from a DL-A identical donor (A" dog); the resulting chimeras have survived uneventfully for 882, 1466 days, with no evidence of secondary disease, and have been tolerant to kidney and skin allografts obtained from the donor of marrow. Treatment of "A" dogs with serum obtained from their long-term "B" chimeras had no significant effect upon the ability of the recipients to reject "B" skin allografts...

Animals↗