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Biomedical subjects

R Baron

Publications and source records attributed to R Baron.

At least 271 records · Page 15Linked to original sources
PubMed1977

A quantitative study of the effects of prolonged calcitonin treatment on alveolar bone remodelling in the golden hamster.

This study was carried out on adult golden hamsters, to correlate the effects of porcine calcitonin on serum Ca and P concentrations with changes in osteoclastic resorption of bone. After 1 month of treatment with 5 MRC units/kg/day, there was little effect on these parameters. On the other hand, the hormone appears to have an effect on the remodelling sequence, as indicated by a large and very significant decrease in the extent of resorption lacunae unoccupied by osteoclasts. It is suggested that the duration of the reversal phase, separating the end of active resorption from the beginning of active bone formation in each remodelling focus, is greatly decreased. This shortening is associated with a prolongation of the bone formation phase, and the extent of osteoid tissue is markedly and proportionally increased in the treated animals. After a prolonged administration, calcitonin does not seem to impede the formation of new osteoclasts, their number being only slightly diminished, but it remains possible that it does continue to inactivate these cells. The effect on the bone remodelling sequence could be either due to direct action on the osteoblasts or their percursor cells, or an indirect action via the osteoclasts.

Animals↗
PubMedDate not supplied

[Muscle function of the thigh 10 years following a malignant bone tumor and implantation of a tumor prosthesis in the knee].

To objectify the muscle function of 5 patients ten years after implantation of a tumor endoprosthesis of the knee simultaneous muscle force and IEMG was recorded. The muscular activity in the operated leg was found to be reduced for the extension muscles (8-20%) and for the flexion muscles (28-52%) when comparing to the normal leg. Knee extension of the operated leg resulted from the function of the rectus femoris muscle. During normal exercise in daily life all patients were not handicapped und some of them did sport.

Adolescent↗
PubMedDate not supplied

Acute life-threatening ventilation-perfusion inequality: an indication for independent lung ventilation.

Although reports of independent lung ventilation are found in the literature more frequently, firm criteria for its use have not yet been established. It is probable that major ventilation-perfusion inequality, especially in cases in which the blood flow is primarily diverted to the less ventilated lung, could sometimes be corrected by this technique. The present report deals with such a case and describes the angiographic studies which convinced us that differential ventilation was necessary. By this means we were able to provide successful treatment for patients who had developed preterminal hypoxemia.

Adult↗