Assessing suffering.
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Biomedical subjects
Publications and source records attributed to R Bayes.
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Neurologic alterations were noted as important early from the description of the AIDS epidemic. At present, there is evidence that the Human Immunodeficiency Virus can be the aetiologic agent of the AIDS dementia complex. The natural history of this disease is not well known. Various longitudinal studies have been undertaken to assess the appearance of neurologic and neuropsychologic alterations in seropositive patients. Until now the results show that asymptomatic seropositive patients have not significant alterations. We are studying seropositive asymptomatic patients with haemophilia. The results of the first year of the study indicate that these patients, taken all together, have not significant alterations. However, neuropsychologic and subtle neurologic alterations were found in 3 patients (21%). If these findings are also observed in other similar studies, these group II "asymptomatic" patients will must be reclassified, with probable changes in management and prognosis.
This study was designed to compare and evaluate the effects of two isocaloric parenteral nutrition infusions, FreAmine and F080, differing in their amino acid composition, on the apparent nitrogen balance and urinary excretion of 3-methylhistidine in children with trauma (n = 27) or grave infection (n = 24). Trauma patients at the beginning of parenteral nutrition showed a more negative nitrogen balance than infected children, but in all children the apparent nitrogen balance increased to become positive and the 3-methylhistidine urinary excretion dropped. No differences related to the amino acid composition of the parenteral nutrition solutions were found. Apparent nitrogen balance and 3-methylhistidine excretion were correlated in all study groups irrespective of urine sample time. The enriched branched chain amino acid solution used for parenteral nutrition of trauma and infected children did not show a better effect than the non-enriched one in terms of muscle catabolism and nitrogen balance. The use of adequate nutritional support including both amino acids and energy source is of major importance in children recovering from trauma and infection.
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