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Biomedical subjects

R Beier

Publications and source records attributed to R Beier.

17 recordsLinked to original sources
PubMed1984

Psychosocial problems in adults with epilepsy: comparison of findings from four countries.

Psychosocial problems in groups of adults with epilepsy from Canada, Finland, the German Democratic Republic, and the United States were evaluated by the Washington Psychosocial Seizure Inventory. A number of similarities in psychosocial concerns were found across the four countries. At the forefront for each group were emotional problems, followed by concerns pertaining to adjustment to the seizures themselves. Where far-reaching governmental support of a financial and vocational nature was lacking, difficulties in these areas were also noted. In all cases, few problems were found in matters pertaining to family relationships and to medical care. Hypotheses to account for differences between the groups were discussed.

Adolescent↗
PubMed1983

[Phenytoin kinetics in toxic serum levels].

After discontinuing Phenytoin, the elimination kinetics was determined in 12 patients with toxic serum levels of more than 30 micrograms/ml. The half-lives of the elimination were between 72 and 122 h (97 h). The Michaelis constant amounted to 16,3 +/- 5,6 micrograms/ml and per day and the maximum rate of metabolism 9,9 +/- 1,1 microgram/ml and per day. The elimination half-lives was dependent on the concentration: the higher the serum concentration the longer the half-live. A method applicable in general practice for determining the course of the serum level with initial values of more than 30 micrograms/ml was described.

Adolescent↗
PubMed1981

[The treatment of epilepsies with Convulsofin].

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.

Adolescent↗
PubMed1979

[Differential indication of trimipramine - results of a controlled multiclinical study].

The antidepressants trimipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective und psychomotoric symptoms. The panthymoleptic action of trimipramine and other antidepressants is discussed with reference to these results. Trimipramine influences psychotic states, especially if in depression anxiety is combined with agitation, also in hypochondriac forms of depression.

Clinical Trials as Topic↗
PubMed1978

[Phenytoin intoxication and serum level].

The symptomatology of phenytoin intoxication was observed in 8.4% of 225 adult patients and in 9.5% of 74 children, with symptoms of cerebellar affection being noted in the majority of cases. Phenytoin concentrations were found to lie between 14.4 and 77.7 microgram/ml. Interindividual differences as to the toxic limit were quite considerable: One third of the patients showing values higher than 20 microgram/ml were free of striking clinical symptoms, and one patient tolerated a serum concentration in excess of 30 microgram/ml. On the other hand, the intraindividual toxic limit did not show any major variations: The clinical symptomatology of a patient correlated with his phenytoin serum concentration. After phenytoin withdrawal, the serum concentration dropped exponentially. The half-life periods of elimination were found to be between 72 and 122 hours.

Adolescent↗
PubMed1977

[Serum phenytoin determination, its value in the treatment of epilepsy].

The concentration of phenytoin in serum was determined by gas chromatography for a total of 101 patients treated on an outpatient basis. In contrast to data reported in the literature, six patients (6 percent) showed therapeutically effective serum concentrations which were far below 7.0 microng/ml. In the majority of cases, however, the therapeutically effective range was from 7.0 to 20.0 microng/ml. A considerable reduction in the frequency of fits was obtained for 23 out of 32 patients who were treated in this manner. Examinations made on patients treated on an inpatient basis showed a definite correlation of daily dose, body weight, and serum concentration. However, interindividual differences were so high that the serum concentration cannot, in general, be safely concluded from the daily dose and body weight. Four percent of the patients showed toxic serum concentrations when normal doses of phenytoin were used. About 50 percent of the patients treated on an outpatient basis showed values indicating very irregular use of the drugs.

Epilepsy↗
PubMed1976

[The significance of fetal electroencephalography for the diagnosis of fetal disorders].

In typical cardiotocographic and bloodgasanalytic changes indicating fetal hypoxia the fetal electroencephalography shows frequency slowing, voltage suppression and spike activity. This EEG tracings simultaneously appeared with first cardiotocographic signs of fetal distress. It was not possible to recognize disturbances of fetal oxygenation in an earlier stage by EEG monitoring. Fetal EEG is of difficult technique and interpretation. In so far cardiotocography is of higher security, sensibility and easier handling for fetal monitoring. With regard to future improvements in electroencephalographic techniques it seems possible to get additional and more accurate informations for fetal monitoring and about perinatal morbidity.

Diazepam↗