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R Ben Osman

Publications and source records attributed to R Ben Osman.

At least 19 recordsLinked to original sources
PubMed1987

Radiological abnormalities of the skeleton in patients with sickle-cell anemia. A study of 222 cases in Tunisia.

The way in which bones are affected in cases of sickle-cell anemia is well known. Nevertheless, advances in treatment and in methods of transfusion mean that we are increasingly seeing cases of older patients with this disease. A retrospective analysis of 222 cases of sickle-cell anemia demonstrates the radiological appearance of the skeleton in the disease and reveals the various bone segments which are particularly vulnerable at certain periods of life. Correlation of X-rays permits the discovery of lesions which are not clinically apparent. The frequency and characteristics of epiphyseal osteonecrosis and osteitis are studied. Aggravation of the bone lesions when corticoids are administered poses the problem of differential diagnosis of the disease, especially in comparison with rheumatic fever.

Adolescent↗
PubMed1986

[Homocystinuria. A type with vascular thrombosis and factor VII deficiency].

In homocystinuria, thrombosis is frequent (50% of the cases). The authors report a case of cystathionine-synthetase deficiency-induced homocystinuria associated with thrombosis of a common iliac vein. This patient presented with a blood coagulation disorder which was related to severe factor VII deficiency and which was corrected by treatment. Homocystinuria was pyridoxine independent as witnessed by the fact that Brand's reaction remained positive with vitamin B6 therapy and cystathionine. Cystathionine-synthetase activity measured in cultured fibroblasts increased only slightly with pyridoxine therapy. Treatment (Betaine, folic acid, vitamin B 12) induced the disappearance of plasma methionine. Clinically, the patient whose treatment came late in the course of her disease, was only slightly improved. Hypotheses about etiopathogenic mechanisms of this disease are discussed. Difficulties of treatment and diet are reviewed. The relative inefficacy of therapy, even in case with early treatment, makes antenatal diagnosis preferable to neonatal diagnosis.

Child↗
PubMedDate not supplied

Safety evaluation of the SAG2 rabies virus mutant in Tunisian dogs and several non-target species.

The safety of the SAG2 rabies virus, a highly attenuated mutant of the SAD strain intended to vaccinate dogs by the oral route, was evaluated in local Tunisian dogs and in five other local species likely to consume vaccine baits. These species were the domestic cat (Felis catus), the jackal (Canis aureus), the jerboa (Jaculus orientalis), the merion (Meriones sp.) and the gerbil (Gerbillus campestris). The vaccine was administered orally to 21 dogs, 11 cats and eight jackals and orally or intramuscularly to 62 wild rodents of the above-mentioned species. Seven dogs, one cat, five jackals all juvenile and with poor health status) and two rodents died for intercurrent causes. The others were observed for 60-180 days. No animal showed any rabies symptom. Seroneutralizing antibodies were observed in all experimental groups, only after vaccination, with the highest rate being observed in jackals and rodents. The rabies virus was detected in the oral cavity of three cats 6 h after oral instillation, but was not isolated later either in saliva or in salivary glands. Tissue samples (brain and salivary glands) from dead or euthanized animals were examined for the rabies virus antigen by a fluorescent antibody test. No rabies antigen was detected. These trials confirm the safety of the SAG2 strain on the Tunisian species already demonstrated by other authors on many other target and non target species.

Administration, Oral↗