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Biomedical subjects

R Benzie

Publications and source records attributed to R Benzie.

15 recordsLinked to original sources
PubMed2005

Ultrasound diagnosis of fetal macrosomia: a comparison of weight prediction models using computer simulation.

OBJECTIVE: To assess the frequency of the diagnosis of macrosomia in relation to differing weight estimation formulae in unselected pregnancies. METHODS: Computer modeling techniques were employed. Computer modeling software generated correlated fetal biometry measurements according to published British standards, from 37 to 41 weeks' gestation. For each set of measurements, estimated fetal weights were obtained by a panel of 18 ultrasound weight formulae. The diagnosis of macrosomia was made if the fetal weight estimate was greater than 4500 g. Cohorts of 5000 pregnancies for each week of gestation were studied. RESULTS: The frequency of diagnosis of macrosomia increased progressively with advancing gestational age, with large increases between 40 and 41 weeks. The type of weight estimation formula had a profound influence on the frequency of diagnosis of macrosomia. Five of the formulae tested almost never returned a weight estimate greater than 4500 g. Three formulae yielded false positive rates in excess of 15%. The Hadlock group of formulae yielded frequencies of 0.3% to 14.6%. CONCLUSIONS: Most formulae tend to over-diagnose macrosomia at term. Intervention rates for suspected fetal macrosomia may be influenced by gestational age at the time of scan and the type of fetal weight estimation formula in use.

Birth Weight↗
PubMed1999

Technical factors in early amniocentesis predict adverse outcome. Results of the Canadian Early (EA) versus Mid-trimester (MA) Amniocentesis Trial.

The purpose of this study was to identify risk factors for fetal loss and other pregnancy complications associated with genetic amniocentesis. Data were acquired in the Canadian Early Amniocentesis Trial (CEMAT), a multicentered (12) prospective, randomized trial comparing continuous ultrasound-guided early amniocentesis (EA) and mid-trimester amniocentesis (MA) (CEMAT Group, 1998). Details of the procedure were recorded and analysed by allocation (EA versus MA), operator and centre, and correlated with pregnancy outcome. A total of 62 spontaneous pregnancy losses occurred between the procedure and 20 weeks' gestation among the 3691 patients who received their procedures within the allocated window (EA=53/1916, MA=9/1775). Technical factors correlating with these losses included procedures 'judged to be difficult' by the operator, and post-procedure amniotic fluid leakage or bleeding. Maternal risk factors included maternal hypertension (fetal loss 11. 1 per cent, compared with non-hypertensive women, 2.6 per cent) increased body mass index (BMI) and gravidity of three or greater. Allocation to EA was predictive of fetal loss, as well as failed procedure, multiple needle insertions, amniotic fluid leakage, failed culture and talipes equinovarus, in excess compared with MA. In conclusion, in this large prospective randomized trial evaluating amniocentesis, specific maternal, fetal and procedural variables were found to be predictive of fetal loss and adverse pregnancy outcome. Performing amniocentesis before 13 weeks' gestation (EA) was the major predictive factor for adverse outcome. These data suggest that first-trimester chorionic villus sampling (CVS) and MA will likely remain the invasive procedures of choice for evaluation of fetal karyotype.

Abortion, Spontaneous↗
PubMed1998

Iraqi time to PAUSE?

Explore the source record for details and available documents.

Health Status Indicators↗
PubMed1993

Fetal tumors associated with hydrops: the role of the pediatric surgeon.

Fetal tumors are being diagnosed with increasing frequency and great accuracy by antenatal ultrasound. High-output cardiac failure and hydrops indicate fetal distress. Management may be limited by the gestational age of the fetus. Our experience with three fetal tumors demonstrates the dilemma with respect to timing of delivery and prognosis. Following the diagnosis of a large sacrococcygeal tumor, a 22-week-gestation fetus became hydropic and died. Another fetus with a rapidly growing posterolateral chest wall mass required cesarean section delivery at 29 weeks gestation. Postnatal course was complicated by pulmonary hypoplasia, intratumoral hemorrhage, and death. The third fetus had an enlarging tumor in the right lobe of the liver. Poor biophysical profile and mild hydrops necessitated cesarean section delivery at 34 weeks. Right hepatic lobectomy was performed and the infant was subsequently discharged home at one month of age. The deleterious effects of the fetal tumor and the need for its removal have to be carefully weighed against the ability of the fetus to survive postnatally.

Adult↗
PubMed1984

The intrauterine diagnosis of hemoglobin disorders.

This article presents an overview of the use of fetal blood and DNA for prenatal testing. The molecular organization of the human hemoglobin genes, the structure of human hemoglobins, and the molecular defects of hemoglobinopathies are also discussed.

Amniotic Fluid↗