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Biomedical subjects

R Beran

Publications and source records attributed to R Beran.

17 recordsLinked to original sources
PubMed2001

AUStralian study of titration to effect profile of safety (AUS-STEPS): high-dose gabapentin (neurontin) in partial seizures.

PURPOSE: To evaluate the safety, tolerability, efficacy, and impact on quality of life of gabapentin (Neurontin; GBP) as adjunctive therapy in patients with refractory partial seizures. METHODS: AUS-STEPS was an open-label, multicenter, prospective study in patients experiencing partial seizures who were inadequately controlled with one to three concurrent antiepileptic drugs (AEDs). GBP treatment was titrated to a maximum of 4,800 mg/day, over a treatment period of 24 weeks, to achieve an efficacious and tolerable dosage. Efficacy was assessed by seizure-frequency data. Quality of life was evaluated by using the QOLIE-10 questionnaire, and safety was assessed by adverse-event reports and clinical laboratory findings. RESULTS: A total of 176 patients received treatment with GBP, with 174 evaluable for intention-to-treat (ITT) efficacy analysis. A reduction of >50% in overall seizure frequency was observed in 93 patients (53%). There was a small (4.6%) overall improvement in QOLIE-10 score. The most frequent adverse events were dizziness (31%), fatigue (29%), somnolence (27%), headache (21%), and ataxia (20%), with no major increase seen in adverse events necessitating discontinuation as the dose of GBP was titrated upward. CONCLUSIONS: This study indicates that patients with partial epilepsy may be effectively treated with GBP at dosages of < or =4,800 mg/day, without altering the safety profile of the drug.

Acetates↗
PubMed1988

Somatosensory evoked potentials, electroencephalography and CT scans in the assessment of the neurological sequelae of decompression sickness.

Decompression sickness can lead to neurological complications. Recovery may be studied by somatosensory evoked potentials (SEPs), which are more sensitive than normal methods of neurological examination, and by electroencephalography (EEG). The combination of EEG and SEP may be useful in differentiating among spinal, brainstem and cortical pathology.

Adult↗
PubMed1981

Myoclonus in Down's syndrome. Association with alzheimer's disease.

Myoclonus and progressive intellectual deterioration developed in a 46-year-old woman with trisomy 21 (Down's syndrome) during the final stages of her illness. Her condition was clinically diagnosed as Creutzfeldt-Jakob disease, but necropsy demonstrated the changes characteristic of Alzheimer's disease and cerebrovascular amyloidosis.

Alzheimer Disease↗
PubMed1979

The neurological aspects of atrial myxoma.

2 cases of left atrial myxoma are presented, with a review of the recent literature on the topic, in order to bring this rare condition to the attention of clinicians. Both cases presented to the Neurological Unit of the Queen Elizabeth Hospital during 1978. The cases helped to emphasise the role of echocardiography in the routine appraisal of the stroke patient, especially if there are multiple lesions or if the patient concerned is young. The second case raised interseting questions regarding electrocardiographic changes associated with altered states of consiousness. Until recently cardiac myxomas were usually a postmortem diagnosis, but now with the effective combination of echocardiography and cine-angiography, cases are being effectively diagnosed and treated. It is hoped that with an increased awareness of the condition, diagnosis will be made sooner and thus prevent more severe sequelae occuring.

Adult↗