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R Bergia

Publications and source records attributed to R Bergia.

35 records · Page 2Linked to original sources
PubMed1986

[Humoral markers of iron status in patients on maintenance hemodialysis].

In forty-nine patients on regular dialysis treatment (RDT) we evaluated following parameters for a period of twenty-four months: serum ferritin (SF), transferrin, T.I.B.C. percental saturation (Fe/TIBC%), haemoglobin (Hb). Twenty-five patients had received more than 5 g intra-venous iron or several blood transfusions, before the beginning of the study, while the other twenty four patients had never received iron treatment nor transfusions. Serum ferritin and Fe/TIBC% proved to be a good estimate of iron stores in RDT patients. In fact both parameters showed significantly higher levels in iron loaded patients than in never treated patients. Furthermore, in patients who no longer received iron loads during the study period, both SF and Fe/TIBC% showed a significant decrease, without changes in haematologic values. This study demonstrated that oral ferritinic iron (40 mg/day for 6 months) doesn't increase either SF and Fe/TIBC% levels, or modifies haematologic values.

Anemia, Hypochromic↗
PubMed1986

[Acute renal insufficiency caused by diflunisal. Description of a case].

A case of kidney failure in a patient with cirrhosis of the liver in the ascitic stage after treatment of a non-steroid anti-inflammatory drug, diflunisal, is reported. The pathogenesis of the kidney impairment, quickly reversed by withdrawal of the drug, is attributed to pharmacological inhibition of cyclo-oxygenase and prostaglandin synthesis with consequent alterations of intrarenal haemodynamics and renal blood flow.

Acute Kidney Injury↗
PubMed1985

[Effects of long-term treatment with L-carnitine on dyslipemia in hemodialysis patients].

The effect of long-term intravenous administration of L-carnitine on the lipid pattern of 18 patients on intermittent haemodialysis has been evaluated. Serum levels of carnitine were assayed at the beginning and after 4 months of treatment: no significant change was observed. At the end of our investigation, we found a significant reduction of HDL-cholesterol and a significant increase of triglyceride levels, compared with basal values. On the contrary cholesterol levels did not change. Five of the patients though behaved as responders to the treatment: their triglyceride levels decrease while their carnitine values rose significantly. The Authors discuss the therapeutic importance of L-carnitine and its possible influence on dyslipaemia of uremic haemodialysed patients.

Carnitine↗
PubMed1983

[Nephrotoxicity of contrast media for urography in patients with chronic renal insufficiency].

The incidence of nephrotoxicity caused by intravenous pielography (IVP) contrast media was retrospectively evaluated in 42 patients with chronic renal failure. In 14 patients renal function was acutely impaired after IVP. In most cases the dysfunction was only temporary; in 3 cases permanent damage was induced, one of which required dialytic treatment. In the cases described there appears to be no correlation between the degree of renal failure and the incidence of nephrotoxicity but the former is clearly linked to the severity of the nephrotoxic response.

Contrast Media↗
PubMed1980

Does renal tubular dysfunction account for the enhanced CAm/CCr ratio in acute pancreatitis?

To verify whether renal tubular dysfunction may account for the CAm/CCr enhancement in acute pancreatitis (AP), we have measured the renal excretion of amylase, lysozyme, and gamma-glutamyl-transpeptidase (GGTP) in 22 patients with AP and in 8 with acute tubular necrosis. While the CAm/CCr ratio was elevated in most patients with AP, the CLys/CCr ratio fell within the normal range in 60% of these patients. The subdivision of patients with AP in subgroups with elevated and normal CLys/CCr ratios revealed a mean CAm/CCr not statistically different. Moreover, no correlation was present in AP between amylase vs. both lysozyme and GGTP clearances. These data suggest that tubular dysfunction does occur in some but not in all the patients with AP and seems not to play a major role in the pathogenesis of the increased CAm/CCr ratio in this condition.

Acute Disease↗
PubMed1979

Amylase to creatine clearance ratio in renal diseases.

In order to assess to what extent glomerular or tubular function is involved in the renal handling of amylase and the lysozyme to creatine clearance ratios (CAm/CCr and CLys/CCr) were evaluated in 22 healthy volunteers and in 71 patients with different renal diseases. In normal controls, the mean CAm/CCr was 2.55 +/-1.54 SD, with an upper normal limit of 5.56. A normal ratio was found in patients with glomerulonephritis, with or without a nephrotic syndrome, and in patients with pyelonephritis. A significantly elevated ratio (P less than 0.001) was instead found in patients with uremia and in patients with uremia and in patients with either chronic or acute tubular damage. The CLus/CCr ratio was elevated in all the groups, except in patients with glomerulonephritis and minimal proteinuria. These results show that in humans, as in animals, the amylase filtered load undergoes partial tubular reabsorption. In renal diseases, an increase of the CAm/CCr is caused by either a marked reduction of functioning nephrons or a severe tubular damage, while the glomerular permeability does not seem to be involved. Some other mechanism is probably involved in the elevation of the CAm/CCr during acute pancreatitis.

Acute Disease↗
PubMedDate not supplied

[Protein metabolism and nutritional status in hemodialysis].

We have studied protein metabolism and nutritional status in a group of patients in regular dialysis treatment. In forty-five patients (mean age 58 +/- 11 yr), undergoing maintenance hemodialysis we have measured protein (DPI) ad caloric (CI) intake by a three-day dietary recall. Protein catabolic rate (PCR) using the urea kinetic model (Gotch' variable volume), anthopometric parameters such as weight, height, midarm circumference, skinfold thickness, midarm muscle circumference (AMC), midarm muscle area (AMA), total muscle mass (TMM) and the percentage of body fat were measured as well. PCR was weakly correlated with DPI. TMM showed a direct relationship with DPI and correlated inversely with UNA/NI (Urea Nitrogen Appearance/Nitrogen Intake). 18% of patients were underweight; 17% showed a decrease of AMA. TMM was inversely correlated with total hospitalization days. There were no significant variations of the examined parameters in a year later evaluation. In our experience TMM is the parameter which better correlates with clinical findings.

Adult↗
PubMedDate not supplied

[Nutritional evaluation of a group of patients with terminal uremia treated with an artificial diet].

The effects of a low protein died supplemented with essential aminoacids (EAA) and keto analogues (KA) on nutritional status have been evaluated in eight chronic uremic patients. After six months of diet, no significant reduction of protidemia (changing from 6.66 +/- 0.5 g/dl to 6.61 +/- 0.8 g/dl) and albuminemia (changing from 4.13 +/- 0.4 g/dl to 3.90 +/- 0.5 g/dl) was observed. Moreover, neither body weight (changing from 70.437 +/- 8.03 kg to 69.500 +/- 8.26 kg) nor total muscular mass (changing from 25.26 +/- 3.83 kg to 25.36 +/- 5.74 kg) showed significant variations. Therefore, in our experience, low protein diet supplement with EAA and KA has not induced any deterioration of nutritional status.

Adult↗