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Biomedical subjects

R Berkseth

Publications and source records attributed to R Berkseth.

8 recordsLinked to original sources
PubMed1986

Rapid high-efficiency hemodialysis.

Reductions in treatment time are attractive for patients and dialysis centers. However, there are concerns related to treatment adequacy and increased intradialytic symptoms. Treatment times were progressively reduced in 12 stable patients on standard 4-h acetate hemodialysis, solute clearances being increased proportionately, until the tolerance limit manifested by increased complications or 2.5 h of treatment was reached. Once shortened schedules (mean reduction approximately 31%) were achieved, a 2-month surveillance period was initiated, followed by 2 additional months of bicarbonate therapy, treatment time being unchanged. Rapid bicarbonate hemodialysis was associated with a significantly lower incidence of hypotension, nausea, and vomiting than rapid acetate or standard acetate therapies. Fluid removal was comparable with that of standard treatment, and serum chemistry levels remained stable. Based on the success of these studies treatment times have been reduced in greater than 200 patients with high-efficiency bicarbonate therapy for long-term evaluations.

Acetates↗
PubMed1984

Peracetic acid for reuse of hemodialyzers clinical studies.

When Renalin was used for reprocessing, the incidences of headache and hypotension were reduced and no changes in serum chemistries were noted. Dialyzer appearance was superior to that achieved with formaldehyde but accompanied by decreases in clearance of urea, creatinine, vitamin B-12 and a fall in KUF. While long-term patient toxicity studies are not yet available, laboratory studies suggest potential problems with carcinogenicity similar to those erroneously attributed to formaldehyde. These data suggest that Renalin may be a suitable alternative to formaldehyde for reprocessing hemodialyzers.

Acetates↗
PubMed1981

Pharmacokinetics of epsilon-aminocaproic acid during peritoneal dialysis.

Two patients requiring peritoneal dialysis were treated with epsilon-aminocaproic acid (EACA), an antifibrinolytic agent. Samples of serum and dialysate were assayed for EACA concentrations. Total body clearance, dialysis clearance, EACA half-life, and volume of distribution of EACA were calculated. Total body clearance of EACA was 26 ml/min, which is 25% of the drug clearance in patients with normal renal function. Our results suggest that patients undergoing peritoneal dialysis should receive 25% of the usual recommended dose of EACA. Dialysis clearance accounted for only 58% of total body clearance, suggesting an alternative route of elimination of EACA.

Aminocaproates↗
PubMed1980

Emphysematous pyelonephritis in a solitary kidney.

Emphysematous pyelonephritis in a solitary kidney was present in a diabetic patient with servere electrolyte imbalance, hyperglycemia, oliguria and electrocardiographic changes suggestive of myocardial infarction. Percutaneous nephrostomy was performed as a life-saving procedure and a week later a large matrix stone obstructing the renal pelvis was removed. The optimal therapy with a surgical or conservative approach is discussed. The use of percutaneous nephrostomy as an initial lifesaving procedure is suggested.

Diabetes Complications↗