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Biomedical subjects

R Bertani

Publications and source records attributed to R Bertani.

8 recordsLinked to original sources
PubMed2007

Solution behaviour and biological activity of bisamidine complexes of platinum(II).

A series of platinum(II) amidine complexes were previously prepared with the aim of obtaining a new class of platinum-based antitumour drugs. This series includes compounds of the type cis--[PtCl2{Z-HN=C(NHMe)Me}2] and trans-[PtCl2{Z-HN=C(NHMe)Me}2] (1, 2), cis-[PtCl2{E-HN=C(NMe2)Me}2] and trans-[PtCl2{E-HN=C(NMe2)Me}2] (3, 4), cis-[PtCl2{Z-HN=C(NHMe)Ph}2] and trans-[PtCl2{Z-HN=C(NHMe)Ph}2] (5, 6), and cis-[PtCl2{HN=C(NMe2)Ph}2] and trans-[PtCl2{HN=C(NMe2)Ph}2] (7, 8). The reactions with dimethyl sulfoxide were studied for complexes 5-8; the formation of cationic species containing coordinated dimethyl sulfoxide was demonstrated by NMR experiments and electrospray ionization mass spectrometry. In this work, the amidine platinum(II) complexes were tested for their in vitro cytotoxicity on a panel of various human cancer cell lines. The results indicate that the benzamidine complex 8 was the most effective derivative also circumventing acquired cisplatin resistance as demonstrated by chemosensitivity tests performed on cisplatin-sensitive and cisplatin-resistant cell lines. The studies concerning the cellular DNA damage on both parental chemosensitive and resistant sublines suggest for the new trans-amidine complex a different mechanism of action compared with that exhibited by cisplatin.

Amidines↗
PubMed2006

Reliability of bioelectrical impedance methods in detecting body fluids in elderly patients with congestive heart failure.

OBJECTIVE: To investigate the reliability of bioelectrical impedance analysis (BIA) in estimating total body water (TBW) and extracellular water (ECW) in elderly patients suffering from congestive heart failure (CHF). MATERIAL AND METHODS: In 72 elderly subjects, 34 with CHF (aged 83.9+/-6.9 years) and 38 healthy controls (78.7+/-7.5 years), TBW and ECW values were assessed using dilution methods, and bioelectrical variables were measured using single frequency BIA (SF-BIA) at 1 and 50 kHz, and bioelectrical spectroscopy (BIS). RESULTS: In CHF patients, Ht(2)/R(1) correlated weakly with TBW (r = 0.56) and ECW (0.47). In both healthy controls and CHF patients, TBW correlated strongly with Ht(2)/R(50), Ht(2)/R(0), Ht(2)/R(8) and Ht(2)/Zc. Using multiple regression analysis and the Bland-Altmann approach, SF-BIA at 50 kHz and BIS proved similar in predicting TBW for both the explained variance (R(2)~0.89) and the limits of agreement. In all subjects, ECW was estimated best by including height, weight and Ht(2)/R(0 )(R(2) 0.75) or Ht(2)/Zc (R(2) 0.77) in multivariate models, while SF-BIA at 50 kHz did not explain more than 71 % of ECW variability. The SEE % was nonetheless about twice the SEE % for estimating TBW. CONCLUSIONS: SF-BIA at 1 kHz is unreliable in predicting body fluids in elderly people with CHF. SF-BIA at 50 kHz and BIS are useful for estimating TBW in healthy elderly people and in cases of water imbalance, but both methods are less reliable in estimating ECW, particularly in conditions of fluid overload.

Aged↗
PubMed1994

Mygalomorph spider bites: a report on 91 cases in the state of São Paulo, Brazil.

From 1966 to 1991 91 cases of bites due to mygalomorph spiders were recorded at the Hospital Vital Brazil, Instituto Butantan, São Paulo, Brazil, representing less than 1% of all spider bites. The diagnosis was confirmed by positive identification of the spider involved. Envenoming is generally mild, the main symptom is local pain, and there is minor oedema and erythema. The data confirm the assumption that these nonaggressive spiders pose no health problem.

Adult↗
PubMedDate not supplied

[Seckel's syndrome].

The case of a girl with Seckel syndrome, born of an epileptic mother who was taking anticonvulsant drugs, is reported. The patient, admitted to our clinic for short stature, presented some signs of Seckel syndrome: microcephaly, a "bird headed" profile with receding chin and forehead and large beaked nose. Microcephaly and a low birth weight are present in Seckel syndrome, but also in the newborn of epileptic mothers who received anticonvulsive drugs. In the present paper the Authors questioned if the described syndrome was caused by the use of antiepileptic drugs during pregnancy, or epilepsy of the mother, or if it was casual.

Abnormalities, Drug-Induced↗