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R Bevilacqua

Publications and source records attributed to R Bevilacqua.

70 records · Page 4Linked to original sources
PubMedDate not supplied

Drug-protein interaction: 8-methoxy psoralen as photosensitizer of enzymes and amino acids.

For a better insight of the molecular basis of the photobiological effects of furocoumarins, the relevance of proteins oxydation by singlet oxygen produced by these substrates under irradiation with long u. v. light was studied. Complex oligomeric as well as simple monomeric purified enzymes with high or low molecular weight and different properties and simple amino acids were irradiated under oxygen in presence of 8-methoxy-psoralen. The effects on both proteins and amino acids were compared with those obtained under similar conditions with typical photosensitizers as methylene blue and Rose Bengal. The results indicated that the photooxydation of proteins, although possible, appears to play a minor role, if any, in the mechanism of action of furocoumarin.

Amino Acids↗
PubMedDate not supplied

[Cardiovascular effects of isometric contraction of the masticatory muscles in humans].

The cardiovascular responses to static exercise do not include, until now, studies about masticatory muscles. In this work the cardiocirculatory effects of the isometric contraction of masticatory muscles were compared with those evoked by the handgrip exercise. Non invasive and, in one case, invasive (aortic catheterism) monitoring of arterial blood pressure was performed. The findings show that mean blood pressure and especially heart rate do not increase during static exercise of masticatory muscles as reported in the literature for other muscular groups: it is suggested that the peculiar architecture of masticatory muscles may explain the absence of significant cardiovascular response to their isometric contraction.

Blood Pressure↗