Biomedical subjects

R Bhattacharya

Publications and source records attributed to R Bhattacharya.

76 records · Page 5Linked to original sources

PubMedDate not supplied

An adaptive response of Vibrio cholerae strain OGAWA 154 to furazolidone.

Since furazolidone is an antimicrobial drug, any possibility of its evoking an adaptive response appears to be very important. This response was studied in Vibrio cholerae cells as a model system. In order to determine this response, a dose-response relation of these cells to furazolidone and the kinetics of inactivation of the drug were studied. The study of the adaptive response of these cells to furazolidone reveals that cells treated with a low concentration of furazolidone for a particular period were 100% more resistant to the lethal effects of a subsequent challenging dose than control cultures. Variation of the challenging dose level showed better survival of adapted cells than control cells. A time-dependent response study reveals a maximum response at 15-30 min, and a gradual fall thereafter.

Acclimatization↗

PubMedDate not supplied

Managerial gaps in the delivery of ante-natal care services in a rural area of Varanasi.

The study was conducted to identify some of the managerial gaps that affect utilization of Antenatal services. Fifty two women aged 15-39 yrs., drawn from 22 households were studied in depth. This article identifies some of the demographic and socio-cultural factors affecting utilization pattern. The degree of utilization was significantly related to education of the woman and her husband's occupation, caste, parity and cultural factors. All women lived within 1 Km from the Health Centre, did not use the services at all, thereby indicating the presence of other factors influencing their attitude towards use of services.

Culture↗

PubMedDate not supplied

Pacing in children and adolescents.

Sixty patients aged 5-16 years underwent implantation of permanent pacemaker and were followed up for 3-11 years. All these patients presented with syncope or symptomatic bradyarrhythmias; two also had congestive cardiac failure in addition, which was ameliorated by pacemaker implantation. A majority of the patients (48) had congenital complete heart block. 8 patients presented with sick sinus syndrome; 4 patients presented with post operative chronic complete heart block. Transvenous endocardial electrode was used in 54 cases and epicardial pacing was done in 6 cases. A majority (55) of the patients received VVI pacemakers; AV sequential pacemakers were implanted in 5 cases. On follow up, the children returned to normal activity and their psychological well being was striking. Reoperation had to be done in 35 cases, a majority being due to over stretching of electrodes (15) and battery exhaustion (12). Two patients died, one due to bacterial endocarditis and the other succumbed to sudden death during vigorous physical activity. Major problems of pacing in children are that veins are often too thin and delicate for electrode insertion, and of the child's growth that stretches the lead system. The problems of pulse generator size and longevity have been partly overcome by introduction of newer models that are small and programmable.

Adolescent↗

PubMedDate not supplied

Intravenous thrombolytic therapy in unstable angina.

One hundred consecutive age and sex-matched patients of 3 different subsets of unstable angina (recent onset angina -65, crescendo angina -20, post-infarct angina-15) were randomized 1:1 after coronary angiography to receive I.V., either 1.5 x 10(6) units of streptokinase (SK) in 200 ml of normal saline or 200 ml of normal saline alone (control) in 1 hour. Repeat angiography was done in those patients having intra-coronary thrombi (37.3%) during the initial angiography. Both groups received optimal doses of heparin followed by warfarin, aspirin and other standard drugs and were followed up for 6 months. Anginal pain subsided significantly in the SK group-41 (82%) vs 25 (50%) (P < 0.005), especially in patients with recent onset angina (92.5% vs 60%, P < 0.005). Incidence of acute myocardial infarction (AMI) was much less in the SKgp (4(8%) vs 17 (34%) (p < 0.05). Four cases of fatal MI and four cases of sudden cardiac death (SCD) occurred in the control group against none in the SKgp. Requirements of mechanical revascularization was significantly less (P < 0.05) in the SK gp. Angiographic evidence of partial or complete clot lysis was noted in 90% of SK gp. vs 4.8% of control (P < 0.01). Echocardiographically assessed LV function improved significantly with SK-therapy in recent onset (P < 0.05) and crescendo angina (P < 0.001) subsets--however, the improvements in post infarct angina subset were not statistically significant. The beneficial outcome with SK therapy was observed in patients irrespective of angiographic evidence of thrombi.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗