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Biomedical subjects

R Bjerke

Publications and source records attributed to R Bjerke.

5 recordsLinked to original sources
PubMed2000

Expanding epidemiology of blastomycosis: clinical features and investigation of 2 cases in Colorado.

On the basis of case reports of blastomycosis, Blastomyces dermatitidis is widely accepted to be endemic in the central United States in and around the Ohio and Mississippi River Valleys. Blastomycosis also occurs in parts of Canada and in the southeastern United States. However, there has been no large-scale skin testing, and the environmental range of B. dermatitidis may have been underestimated. We describe 2 immunocompetent patients with blastomycosis acquired while working in the Front Range region of the Rocky Mountains. The patients were coworkers engaged in a prairie dog relocation project. In the course of this work, they had extensive contact with contaminated soil. Significantly above-average rainfall before the exposure may have contributed to favorable conditions for sporulation of the fungus.

Adult↗
PubMed1999

Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea.

Previous investigations have indicated that topical azelaic acid has beneficial effects in rosacea. This 3-month randomized, double-blind, multicentre study compared the efficacy and safety of azelaic acid 20% cream with its vehicle, in the treatment of papulo-pustular rosacea. A total of 116 patients were enrolled in the study and medication was applied twice daily. Azelaic acid cream produced significantly greater mean reductions in total inflammatory lesions than did vehicle (azelaic acid: 73.4%; vehicle: 50.6%; (p = 0.011), and erythema severity score (azelaic acid: 47.9%; vehicle: 37.9%; (p = 0.031). Azelaic acid cream treatment also resulted in significantly more favourable overall improvements than vehicle in both physician (p = 0.020) and patient ratings (p = 0.042). Neither azelaic acid cream nor vehicle produced any clinically relevant improvement in telangiectasia. Local adverse events were transient and mainly mild or moderate, and rates were similar for azelaic acid cream (39.5%) and vehicle (38.5%). Burning was the symptom most frequently reported. More than 90% of patients rated the overall local tolerability of their treatment as good or acceptable. In conclusion, azelaic acid 20% cream is effective and well tolerated in the treatment of papulo-pustular rosacea.

Administration, Cutaneous↗
PubMed1997

Hemodynamic effects of inhaled nitric oxide in four patients with severe liver disease and pulmonary hypertension.

Patients with moderate and severe pulmonary hypertension have a very high mortality rate when undergoing orthotopic liver transplantation. Because nitric oxide has been successful in reducing pulmonary artery pressures in certain patients with pulmonary hypertension, the efficacy of NO inhalation (40 and 80 ppm) in 4 patients with pulmonary hypertension associated with liver disease was determined. No clinically significant changes in pulmonary artery pressures or other hemodynamic parameters were observed using either concentration of NO. In conclusion, no pulmonary vasodilatory response from inhalation of NO in 4 patients with severe liver disease and pulmonary hypertension was found.

Adult↗
PubMed1988

Rapid-sequence induction technique in patients with severe ventricular dysfunction.

The hemodynamic effects of a rapid-sequence induction and intubation technique using etomidate, fentanyl, and succinylcholine for emergency surgery in patients with severe ventricular dysfunction were studied. Ten patients undergoing orthotopic heart transplantation received fentanyl, 10 microg/kg, etomidate, 0.3 mg/kg, and succinylcholine, 1.5 mg/kg, intravenously (IV) in rapid-sequence fashion for induction. Intubation was performed 60 seconds later. Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary arterial pressure (MPAP), pulmonary arterial occlusion pressure (PAo), and cardiac index (CI) were measured preinduction, postinduction, and 1 minute after intubation. Systemic vascular resistance index (SVRI) and pulmonary vascular resistance index (PVRI) were calculated from the measured data. No statistically significant changes in hemodynamics occurred with induction or intubation. These results indicate that etomidate, fentanyl, and succinylcholine given in a rapid-sequence technique produce a hemodynamically stable induction with minimal response to intubation in patients with end-stage cardiac disease.

Adult↗