PubMed Health⌕ Search

Biomedical subjects

R Bolton

Publications and source records attributed to R Bolton.

33 records · Page 2Linked to original sources
PubMed1988

A simplified scheme for the investigation of thyroid function in chronic liver disease.

The investigation of thyroid disease in the presence of chronic liver disease (CLD) is difficult. Conventional tests are influenced by chronic illness and abnormal concentrations of binding proteins. A three tier system is normally used; thyroxine (T4), then T3 or TSH and an index for binding proteins. The recently introduced TSH immunoradiometric assays (IRMA) offer the potential of a single test assessment of thyroid function. This was assessed by the measurement of T4, T3, THBC and the free thyroxine indices in subjects with CLD. Conventional tests showed a high number of abnormal T4 values but binding indices were normal. The TSH-IRMA results were all normal. TSH-IRMA assays are rapid, easy to use and cheap. They remove the uncertainties in assessing thyroid function in CLD and may be the test of choice.

Adolescent↗
PubMed1988

Acute ethanol ingestion raises plasma gamma amino-butyric acid levels in healthy men.

The effect of acute ethanol ingestion on plasma gamma aminobutyric acid (GABA) levels was investigated in eight volunteers. Subjects were studied on two days: a control during which light activity and non-alcoholic fluid intake was allowed and a study day during which ethanol was ingested to maintain blood alcohol levels at a mean of 130 mg%. Plasma GABA levels were estimated at 1, 4 and 8 hr. GABA levels were raised at 1 and 4 hr on the study day compared to the control day. GABA levels at 8 hr were not significantly different on the two days. Acute alcohol ingestion raised plasma GABA in healthy male volunteers.

Adult↗
PubMed1983

The effect of glucagon on the swallowing of capsules.

Glucagon (0.3 mg) given intravenously to 45 patients with normal oesophageal motility significantly reduced oesophageal transit of hard gelatin capsules when swallowed in the supine position with 15 ml water, compared to an age/sex matched group. This is taken to represent an effect on oesophageal peristalsis which has not previously been recognised.

Adult↗
PubMed1969

Viral antibodies in diabetes mellitus.

Sera from 123 patients with diabetes mellitus of recent onset, 155 patients with diabetes of more than two years' duration, and 250 normal persons were collected over a period of two and a half years. All sera were tested for neutralizing antibody to Coxsackie virus types B1-6, and a sample was tested for complement-fixing antibody to a number of viral, rickettsial, and mycoplasmal antigens.In diabetics of recent onset no evidence was found of any excess of antibodies to mumps virus or some common respiratory viruses. Insulin-dependent diabetes within three months of onset were found to have higher antibody titres to Coxsackie B virus, particularly of type B4, than either normal subjects or patients with diabetes of longer duration.

Adolescent↗