PubMed Health⌕ Search

Biomedical subjects

R Boni

Publications and source records attributed to R Boni.

32 records · Page 2Linked to original sources
PubMed1985

[Circadian and circannual study of the hypophyseal-gonadal axis in healthy young males].

Circadian and circannual variations of Testosterone, FSH and LH secretions, other than Oral Body Temperature (OBT) have been studied in four healthy males. OBT showed a constant circadian rhythm with an acrophase located in the afternoon. Plasma Testosterone exhibited both a circadian (acrophase = hr 09,28) and a circannual rhythm (acrophase = 22 february); plasma FSH also showed a circannual rhythm (acrophase = 13 february). By mean chronogram +/- SEM we documented the highest LH levels in December and the lowest in February. These observations would suggest the hypothesis that the winter could be the period in which the hypophysis-gonadal axis in young males exhibits its maximal activity as previously documented for other hormones.

Adult↗
PubMed1984

[Circadian and circumannual variations in the level of plasma TSH and prolactin in healthy adult males].

4 healthy young volunteers were submitted to the study of circadian and circannual oscillations of plasma TSH and Prolactin. Our data demonstrated the existence of a circadian rhythm for TSH with acrophase at 04,39 and a circannual rhythm of the same hormone with acrophase in January. While for Prolactin it was possible to detect a circadian rhythm with acrophase at 04,29. We failed to demonstrate any circannual variation of plasma hormonal levels.

Adult↗
PubMedDate not supplied

Effect of emulsifier blend on the characteristics of sustained release diclofenac microspheres.

This investigation involved the evaluation of the emulsifier blend effect on the development of sustained release diclofenac microspheres intended for use in a suspension formulation. The microspheres were prepared using the hydrophobic congealable disperse phase method. The emulsifier blend consisted of glycerol, monostearate (GMS), a hydrophobic emulsifier with HLB = 3.8, and Tween 80, a hydrophilic emulsifier with a HLB value of 15. The effect of this blend on the encapsulation efficiency, size distribution and drug release from the microspheres was studied. A critical amount of GMS (> 0.2 g) was found to be necessary for good encapsulation efficiency. X-ray diffractograms revealed that the drug retains its crystalline state within the microspheres, indicating that the drug is present as a dispersion within the wax matrix. Increasing amounts of Tween 80 caused an increase in the drug release while increased amounts of GMS retarded the release. The hydrophilic emulsifier and the emulsifier blend influenced the size distribution of the formed microspheres. With an increase in the amount of hydrophilic emulsifier, there was an initial increase in the percent of desired size fraction (137.5 microns) of microspheres followed by a decrease. Microspheres with a larger size released the drug slowly compared to smaller size microspheres, while increase in drug load increased the rate of drug release. The release pattern fitted the Higuchi dissolution kinetics for spherical matrices. Different impeller blade designs formed microspheres that exhibited different release rates. The microspheres (mean size 137.5 microns), had a release profile that made them suitable to be formulated as a sustained release suspension.

Anti-Inflammatory Agents, Non-Steroidal↗