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Biomedical subjects

R Bontemps

Publications and source records attributed to R Bontemps.

8 recordsLinked to original sources
PubMed1982

Application of conventional (DC) and differential pulse polarography (DPP) to the quality control of benzothiadiazines in tablets. Simultaneous determination of hydrochlorothiazide and dihydralazine sulphate in mixtures with minimization of interaction by the use of a zero covariance in the calibration.

A previous study of the polarographic behaviour of 14 benzothiadiazines having diuretic properties enabled possible reaction mechanisms to be proposed and gave the opportunity to determine the best conditions for analytical application. The results obtained with benzthiazide as an example of the unsaturated compounds, bendrofluazide as the dihydro compound, and hydrochlorothiazide determined together with dihydralazine are reported. The electroactivity of these last two substances was made the object of a mathematical study for the correction of reciprocal interference.

Bendroflumethiazide↗
PubMed1979

Thallium-201 myocardial scintigraphy in patients with triple-vessel disease and ischemic exercise stress tests.

Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent of these patients showed ischemia by 201TI scintigraphy, of which one-half returned to normal after surgery. Postoperative reversion of the ECG stress test together with 201TI stress/reperfusion imaging correlated well with the completeness of surgical revascularization. We could not explain the prevalence (80%) of infarcts detected by 201TI in this group, of which 76% could be anatomically correlated to epicardial scars. The positivity of infarcts by 201TI exceeded that predicted by previous history of infarction, Q waves on resting ECG or ventriculographic akinesis. These observations suggest that 201TI scintigraphy is a useful noninvasive tool in the follow-up and understanding of patients with coronary heart disease. These conclusions also support the concept that 201TI stress imaging need not have the identical connotation as the ECG stress test.

Adult↗
PubMed1977

Scintigraphic diagnosis of ischemic intestine with technetium-99m sulfur colloid-labeled leukocytes.

Positive scintigrams were obtained in 13 of 15 dogs injected with technetium-99m sulfur colloid-labeled leukocytes following the experimental production of intestinal ischemia. The radioactivity of the ischemic intestines averaged 5.9 times that found in normal control segments of intestine from the same animal. Labeled leukocytes may be used as a rapid noninvasive technique for the early identification of ischemic intestine.

Animals↗