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Biomedical subjects

R Bowling

Publications and source records attributed to R Bowling.

4 recordsLinked to original sources

Optimising assay sequence on automated coagulation instrumentation.

An embedded knowledge-based system has been developed to determine the optimum sequence for assays performed on a random access coagulation analyser. This knowledge base is in the form of a set of rules describing penalties associated with certain sequences of assays. The optimisation of assay sequences increases throughput and reduces consumption of cleaning solutions and generation of waste. A flexible design also facilitates updates to the knowledge base as assays are modified and added in the future.

Artificial Intelligence↗

Emergency pneumonectomy for penetrating and blunt trauma.

Emergency pneumonectomy for penetrating and blunt trauma has an attendant high mortality. Patients with major lung injuries presenting with prolonged shock followed by control of bleeding, resuscitation with or without aortic cross-clamping and pneumonectomy have had uniformly unsatisfactory results. From 1972 to 1982, eight patients at the University of Louisville Hospital underwent emergency pneumonectomy. All patients underwent expeditious evaluation, resuscitation, and thoracotomy with pneumonectomy. Three patients died of exsanguination (2 patients had major associated intra-abdominal injuries). Three other patients died due to pulmonary edema and right ventricular failure 2 to 3 hours after hemorrhage had been controlled and intravascular volume restored. Aortic cross-clamping was employed in four patients due to persistent hypovolemia with 100 per cent mortality. Of the two surviving patients, one presented with stable blood pressure and had pneumonectomy for tracheobronchial disruption, while the other had pneumonectomy for tangential laceration of the lung at the hilum. Pulmonary edema and right ventricular failure were responsible for mortality following emergency pneumonectomy and control of hemorrhage and restoration of blood volume. The addition of aortic cross-clamping did not seem to alter survival and may, indeed, hinder therapy due to increased vascular afterload and increased heart failure and pulmonary edema.

Adult↗