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Biomedical subjects

R Bown

Publications and source records attributed to R Bown.

8 recordsLinked to original sources
PubMed1984

Jejunal motility in patients with functional abdominal pain.

A radiotelemetric system using dual pressure pills was used to record the jejunal motility in man. Prolonged recordings were made under relatively physiological conditions. Six patients with functional abdominal pain and six age/sex matched normal subjects were studied. Motility patterns varied markedly both within and between subjects. No differences were detected between the two groups. In particular, the occurrence of characteristic pain in the patients bore no relation to the recorded motor activity. The wide range of jejunal motility patterns in normal subjects needs to be appreciated before conclusions can be drawn about possible abnormalities in gut diseases or disorders.

Adult↗
PubMed1979

Pericarditis and inflammatory bowel disease.

Pericarditis is an uncommon but important complication of inflammatory bowel disease. Five new cases are described and the published literature on nine other cases is reviewed. The pericarditis occurred during an active phase of the colitis in all our cases and was associated with other extra-colonic manifestations of colitis in three. No other cause for the pericarditis was identified and in all five cases it responded promptly to the administration of corticosteroid drugs.

Adolescent↗
PubMed1973

The effect of perfusion on the flora of the excluded colon.

The bacterial flora of excluded colonic segments of three patients has been examined in the normal resting state and following perfusion.The flora of the excluded colon was substantial and qualitatively similar to that of faeces. Perfusion for two hours at 10 ml per minute usually reduced counts of organisms present in the issuing effluent by 1 to 1(1/2) logs in two patients, but rises in the counts of some organisms were recorded from the third patient. Prolonged rapid perfusion or the inclusion of antibiotics in the perfusing solution was necessary to obtain a substantial reduction in counts. Rapid perfusion resulted in the appearance of organisms that had not been recovered during slower perfusions.

Bacteroides↗
PubMed1972

Cell-mediated immune reactivity in liver disease.

Cell-mediated immunity has been investigated using the leucocyte migration test in 32 patients with chronic active hepatitis or primary biliary cirrhosis. Twenty-six (75%) showed reactivity to liver extract. At least two antigens are involved. Cell-mediated reactivity was confirmed in some cases using lymphocyte ;blast' transformation. There was no correlation with the presence of auto-antibodies.Cell-mediated immunity to parotid extract was shown in 10 cases (28%). This is in accord with the occurrence of the sicca syndrome in liver disease, which has been confirmed in this study.

Antigens↗
PubMed1970

"Sicca complex" in liver disease.

Sixty-three patients with liver disease were studied for the presence of the components of Sjögren's syndrome. The "sicca complex" (that is, patients without arthritis) was detected in 42% of patients with active chronic hepatitis, 72% with primary biliary cirrhosis, and 38% with cryptogenic cirrhosis. One patient with active chronic hepatitis and one with primary biliary cirrhosis had rheumatoid arthritis. No evidence of Sjögren's syndrome was detected in seven patients with alcoholic cirrhosis. It is suggested that the sicca complex and autoimmune liver disease may be part of a systemic disorder in which immunological mechanisms are concerned in the pathogenesis.

Adult↗