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Biomedical subjects

R Braswell

Publications and source records attributed to R Braswell.

3 recordsLinked to original sources
PubMed1982

Comparison of thiopentone and midazolam for induction of anaesthesia: influence of diazepam premedication.

Forty-eight healthy patients undergoing routine surgery participated in this double-blind parallel study in which thiopentone sodium and midazolam maleate were compared for induction of anaesthesia. Twelve patients in each group received diazepam premedication. The purpose of this study was three fold; first to compare the efficacy of these two drugs as induction agents using fixed criteria, second to find the optimal dose of midazolam for induction and, finally, to evaluate the effects of diazepam premedication on the induction dose of both drugs. The results showed that adequate induction of anaesthesia was achieved using 0.30 milligrams per kilogram of midazolam and 3.99 milligrams per kilogram of thiopentone. These doses were not altered by pre-operative medication with diazepam. The recovery time was significantly prolonged in those patients who had received midazolam. The shortest recovery time was observed in those patients who had received thiopentone with diazepam. There were four cases of phlebitis in the thiopentone group and two in the midazolam group. In conclusion, midazolam maleate, which is a water soluble benzodiazepine, provided satisfactory induction of anaesthesia at a dose of 0.30 milligrams per kilogram. However, recovery time was significantly prolonged in patients who received midazolam.

Adult↗
PubMed1981

Ligation of patent ductus arteriosus in premature neonates: anesthetic management.

A retrospective study covering a five-year period was conducted on 40 premature neonates who had had general anesthesia for surgical correction of patent ductus arteriosus. The anesthetic management of these patients was carefully reviewed. The mean weight at surgery was 1,243 gm, and the mean gestational age at birth was 29.5 weeks. Various technics of anesthesia were used, the most common being the use of nitrous oxide, oxygen, relaxant, and narcotics. There were no intraoperative deaths. Two patients had massive blood loss intraoperatively. There were 12 postoperative deaths in the series, and 12 patients had serious long-term disability, many were combinations of hearing, visual, and psychomotor disturbances. Advances in neonatology, surgery, and anesthesiology have improved the outlook of these seriously ill patients.

Anesthesia, General↗