PubMed Health⌕ Search

Biomedical subjects

R Breeze

Publications and source records attributed to R Breeze.

12 recordsLinked to original sources
PubMed2001

Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease.

We assessed nigrostriatal dopaminergic function in Parkinson's disease (PD) patients undergoing a double-blind, placebo-controlled surgical trial of embryonic dopamine cell implantation. Forty PD patients underwent positron emission tomography (PET) imaging with [18F]fluorodopa (FDOPA) prior to randomization to transplantation or placebo surgery. The 39 surviving patients were rescanned one year following surgery. Images were quantified by investigators blinded to treatment status and clinical outcome. Following unblinding, we determined the effects of treatment status and age on the interval changes in FDOPA/PET signal. Blinded observers detected a significant increase in FDOPA uptake in the putamen of the group receiving implants compared to the placebo surgery patients (40.3%). Increases in putamen FDOPA uptake were similar in both younger (age < or = 60 years) and older (age > 60 years) transplant recipients. Significant decrements in putamen uptake were evident in younger placebo-operated patients (-6.5%) but not in their older counterparts. Correlations between the PET changes and clinical outcome were significant only in the younger patient subgroup (r = 0.58). The findings suggest that patient age does not influence graft viability or development in the first postoperative year. However, host age may influence the time course of the downstream functional changes that are needed for clinical benefit to occur.

Adult↗
PubMed1999

Bilateral partial laminectomy: a treatment for lumbar spinal stenosis and midline disc herniation.

BACKGROUND: Lower back pain is extremely common; most patients' symptoms improve with conservative treatment. This leaves only a small percentage of patients with persistent symptoms that are amenable to surgery. Various decompressions have been performed to remedy compressive conditions of the spine, with a wide range of results. METHODS: We retrospectively reviewed 152 patients with lumbar spinal stenosis or midline disc herniations surgically treated with bilateral partial laminectomy. Short-term follow-up was available for 138 patients (2 weeks to 2 months) and long-term follow-up was available for 88 patients (1-6 years, mean 3.5 years). Clinical outcome was determined by chart review and the use of a standardized questionnaire. Preoperative and postoperative back and leg pain, ambulation, employment status, and satisfaction were assessed. RESULTS: Overall improvement postoperatively was noted in 88% of the spinal stenosis patients and 91% of the midline disc herniations at long-term follow-up. Average hospital stays for the spinal stenosis group and the midline disc herniation group were 3.7 days and 2.8 days, respectively. Only two patients had undergone subsequent fusions of their lumbar spine after bilateral partial laminectomy. CONCLUSION: We believe that less radical resection of laminae and spinous processes better preserves the spine's natural architecture and may contribute to improved postoperative stability. This may reduce the number of patients needing concomitant or subsequent fusion, with its associated morbidity. As surgeons push for less radical or less invasive surgical techniques to obtain the same or better postoperative results, the bilateral partial laminectomy is a good alternative to total laminectomy.

Adult↗
PubMed1985

Structure, function, and metabolism in the lung.

Research into the molecular basis of cellular injury and repair will lead to advances in our understanding of the pathogenesis of infectious and noninfectious respiratory disease in cattle. In order to appreciate these advances fully, it is necessary to define the basics of structure, function, and metabolism in the respiratory system.

Animals↗
PubMed1985

Parasitic bronchitis and pneumonia.

Parasitic bronchitis and pneumonia is often a serious problem on individual farms, despite the fact that the disease is easy to diagnose, easy to treat, and easy to prevent by anthelminthic control programs or by vaccination. This article presents the various phases of the primary infection as well as the reinfection syndrome.

Animals↗
PubMed1985

Respiratory disease in adult cattle.

This article discusses the nomenclature of respiratory disease, acute respiratory distress syndromes, hypersensitivity diseases, chronic respiratory disease, and the differential diagnosis of respiratory disease.

Alveolitis, Extrinsic Allergic↗
PubMed1985

New technology for prevention and control of infectious bovine respiratory diseases.

Recent advances in molecular biology, genetics, and immunochemistry have provided the basis for a new generation of vaccines, diagnostic tools, and prophylactic substances for the prevention of infectious diseases in cattle. This article describes how these new technologies are being applied to veterinary medicine and their potential in bovine respiratory diseases caused by infectious agents.

Adjuvants, Immunologic↗
PubMed1977

Immunization of sheep against a virulent strain of Schistosoma mattheei using a strain of S. mattheei attenuated by hamster passage.

We have previously described the characteristics of a relatively non-pathogenic laboratory strain of S. mattheei, attenuation of which was apparently caused by passage in hamsters. We now show that chronic infection with this avirulent strain largely protects sheep from the manifestations of acute schistosomiasis when challenged with a virulent strain of S. mattheei. Four sheep were each infected with 10 000 cercariae of the avirulent strain and, together with four wormfree sheep, challenged 63 weeks later with 10 000 S. mattheei cercariae of a pathogenic strain. Four more sheep acted as uninfected controls. Following challenge, the animals were weighed and bled weekly for PCV and serum protein determinations, and egg counts were carried out fortnightly on faeces taken from the rectum. Red cell and albumin turnover were monitored for two weeks immediately before challenge and for a similar period before necropsy, when the adult worms were recovered by perfusion and tissues sampled for histopathology and egg counting. The unvaccinated sheep developed severe disease 6-12 weeks after exposure characterised by marked anaemia, hypoalbuminaemia and hyper-gamma globulinaemia coinciding with the passage of blood-stained faeces and progressive inappetence. In the vaccinated sheep, there was an even earlier rise in gamma globulins, but the other clinico-pathological changes were generally slower to devleop and much milder in severity. The parasitological data showed that although this was partly due to a reduction in the establishment of the challenge worm population the main factor was probably a reduction in the fecundity of these worms.

Animals↗
PubMedDate not supplied

Intracalvarial cholesterol granulomas--clinicopathologic correlates of three cases.

Cholesterol granulomas (CGs) are tumor-like lesions seldom encountered by neuropathologists. CGs develop in reaction to localized hemorrhage, often occurring in bony sites with possible impaired drainage of blood and blood products. The most common bony location is the petrous apex, although orbital, frontal sinus, and maxillary sinus sites have been reported. We compare and contrast three recent cases seen at our institution that illustrate the spectrum of clinical, radiographic, and pathologic features that can be seen with these mass lesions. One case demonstrated the unique pathological features of Gamma-Gandy body formation, epithelioid histiocytes heavily encrusted with iron pigments, and extensive tophi. The latter most likely represented aggregates of calcium pyrophosphate crystals associated with extensive iron deposition.

Adult↗