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Biomedical subjects

R Brubaker

Publications and source records attributed to R Brubaker.

10 recordsLinked to original sources
PubMed1993

The vibration characteristics of chain saws and their influence on vibration white finger disease.

The vibration from chain saws can cause vibration-induced white finger disease (VWFD). Measurements of vibration levels on the front and rear handles of different chain saw-types, and on the operator's middle finger were collected at three logging camps on Vancouver Island. Factors effecting the vibration levels on the finger and handles were investigated. The acceleration at the firing frequency was found to be the dominant factor effecting handle and finger vibration. Other factors which were investigated were: grip force; the presence of handle covers; and chain sharpening procedure. Weighted acceleration levels are calculated and this information is used to assess the latency period for fallers to develop VWF disease.

Equipment Design↗
PubMed1992

Protein S deficiency and skin necrosis associated with continuous ambulatory peritoneal dialysis.

Skin necrosis associated with protein C deficiency has recently been reported to occur in hemodialysis patients. The clinical presentation and course of this syndrome appears indistinguishable from skin necrosis (purpura fulminans) seen in other settings with inherited or acquired deficiency of the naturally occurring anticoagulant proteins, protein C and S. Patients on maintenance hemodialysis may have low levels of these factors. However, patients on peritoneal dialysis have normal or elevated levels of these proteins despite documented peritoneal losses. We report two patients in whom the occurrence of protein S deficiency and subsequent skin necrosis can be related to demonstrated peritoneal dialysis-associated losses. We suggest that these losses may become critical under appropriate conditions and suggest caution in peritoneal dialysis patients requiring warfarin therapy.

Blood Proteins↗
PubMed1990

Plasmacytoid T-cells in a reactive lymph node. Detection by flow cytometry?

Plasmacytoid T-cells (PTCs) are a histologically recognized component of some reactive nodes. To the best of the authors' knowledge, plasmacytoid T-cells have never been recognized as a distinct cell population in a reactive lymph node using cell suspension flow cytometric studies. The authors here report a case of reactive lymph node hyperplasia in which prominent aggregates of PTCs were present and a distinct cell population with an immunophenotype characteristic of PTCs was identified by flow cytometry. Aside from the recognition of PTCs, this observation is important so that cell suspensions showing a distinct population of PTCs with an "aberrant" T-cell phenotype are not misinterpreted as providing evidence for a T-cell neoplasm.

Adult↗
PubMed1985

Fluorescent, physiological and pharmacokinetic properties of fluorescein glucuronide.

When fluorescein is administered systemically, it is metabolized to form a fluorescent compound, fluorescein monoglucuronide. The molar fluorescent intensity of this compound is less than that of fluorescein but its fluorescent intensity compared to fluorescein varies considerably depending on the wavelength employed for excitation. Several hours after oral or intravenous administration the conjugate can become the dominant fluorophore in the plasma. When fluorescein is administered systemically and fluorescent intensity is measured in the eye, it is necessary to determine which compound is being measured since the time courses of the plasma concentrations and the permeability of the ocular barrier of each compound may not be the same. A technique suitable for measuring the relative concentration of each fluorophore in ocular tissues in vivo is suggested.

Aqueous Humor↗
PubMed1978

Developmental features of speech-sound production in language-impaired children.

The speech-sound production of severely language-impaired children was monitored in a longitudinal study. In order to generalize findings, acoustical, phonemic, and clinical observation data were collected from 30 children. Results showed that speech-sound acquisition goes through a hierarchical sequence of development and that speech-sound production will deteriorate in a predictable manner depending on the pathology. The authors hypothesize a speech-sound acquisition model, SSAM, based on the development observed.

Acoustics↗
PubMedDate not supplied

Fatalities among British Columbia fallers and buckers 1981-7.

In Canada, the forest industry has the highest rate of lost time injury (161 per thousand workers in 1986) and has the highest fatality rate (1.04 per thousand workers in 1986) of all industries. A retrospective case series of fatal accidents occurring among those employed as fallers or buckers in the British Columbia Forest Industry was studied. 87 cases were found and the files of the provincial coroner were accessed to provide data on these accidents. Due to a lack of denominator data, no risk factors could be identified by several hypotheses for future research were developed. These included: the possibility that lack of work experience and young age may play a role in these accidents, the observation that there are "peaks of incidence" just before noon, on Mondays and Thursdays and in January. There was also the surprising finding of the lack of toxicological evidence indicating impairment of any of these workers. Future directions for research are discussed.

Accidents, Occupational↗