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Biomedical subjects

R Buratti

Publications and source records attributed to R Buratti.

4 recordsLinked to original sources
PubMed1995

Calcium dependent activation of skeletal muscle Ca2+ release channel (ryanodine receptor) by calmodulin.

In this study terminal cisternae vesicles from rabbit skeletal muscle were fused into planar bilayers and the effect of calmodulin on single Ca2+ release channel currents was investigated. In the presence of 10(-7) and 10(-9) M free [Ca2+], nanomolar concentrations of calmodulin activated the channel by increasing the open probability of single-channel events in a dose dependent manner. The activatory effect of calmodulin was reversed by 10 microM ruthenium red. At 10(-5) M free [Ca2+], calmodulin (0.1-1 microM) inhibited channel activity. Calmodulin overlays were carried out using concentrations of Ca2+ similar to those used for the planar lipid bilayer assays. In the presence of 10(-7) M [Ca2+], calmodulin bound to the ryanodine receptor, to a region defined by residues 2937-3225 and 3546-3655. These results suggest that calmodulin may activate the Ca(2+)-release channel (ryanodine-receptor) by interacting with binding sites localized in the central portion of the RYR protomer.

Animals↗
PubMed1993

[Reliability of sedation in MRI].

In our work we have an enumeration of 1527 sedation cases to carry out RM exams with non co-operating patients, most of them in pediatric age. During the examination the patients were monitored using oximeter and observed by closed circuit camera. The meaningless complications head us to think that deep sedation is a reliable procedure which allows us to work out RM exams during a day-hospital regime.

Adolescent↗
PubMed1986

Rotational pedicle grafting.

The rotational pedicle graft, as adapted for use on the plantar aspect of the foot, is a valuable tool for repairing painful defects of the weight-bearing surface. The procedure described here lends itself particularly well to repair of defects beneath the second and third metatarsophalangeal joints, although it also has application on the heel and other weight-bearing surfaces.

Foot↗