SacI RFLPs at the D8S51 locus.
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Chromosomes, Human, Pair 8↗
Biomedical subjects
R Burdiek
Publications and source records attributed to R Burdiek.
Asp700 RFLP at the D8S45 locus.
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Chromosomes, Human, Pair 8↗
Two RFLPs at the D8S42 locus.
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Chromosomes, Human, Pair 8↗
Two RFLPs at the D8S50 locus.
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Chromosomes, Human, Pair 8↗
Three RFLPs at the D8S49 locus.
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Chromosomes, Human, Pair 8↗
Maternal origin of a de novo chromosome 8 deletion in a patient with Langer-Giedion syndrome.
The anonymous DNA probe L32, which defines the D8S48 locus within the Langer-Giedion syndrome chromosome region on the long arm of chromosome 8, was used to search for a common restriction fragment length polymorphism. A HindIII and an MspI polymorphism were detected (polymorphism information contents 0.25 and 0.19, respectively). Both polymorphisms were informative in the family of a Langer-Giedion patient carrying a de novo interstitial deletion 8q23-24.1. Lack of transmission of a maternal haplotype indicates that this deletion occurred during maternal gametogenesis. This finding contrasts with the frequent paternal origin of mutations in other microdeletion syndromes.
Chromosome Banding↗