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Biomedical subjects

R Burks

Publications and source records attributed to R Burks.

7 recordsLinked to original sources
PubMed1992

Detection of occult tumor using indium 111-labeled anticarcinoembryonic antigen antibodies.

Even with the advancement of radiologic techniques, metastatic cancers can still be difficult to detect. In this study, 48 patients suspected of having occult metastases were studied by radioimmunodetection following the administration of 92.5 to 181.3 MBq of indium 111-labeled monoclonal anticarcinoembryonic antigen antibody. All but seven patients were thought to have metastatic colorectal carcinoma. In the majority of cases, physical examinations and computed tomographic scans had failed to detect a lesion. At least one lesion that was later proved to exist was detected in 34 of the 50 studies performed on these patients. Seven of eight patients with normal radioimmunodetection scans remain free of disease. One hundred one sites were detected overall; 60 were considered true-positive sites and 27 false-positive sites. Fourteen sites remained in question. Nineteen false-negative sites occurred. Radioimmunoimaging appears valuable for the detection of occult cancer where standard, noninterventional techniques have failed to detect the suspected disease.

Carcinoembryonic Antigen↗
PubMed1986

Dermis-fat graft for orbital reconstruction after subtotal exenteration.

A surgical technique for reconstruction after subtotal orbital exenteration uses an autogenous dermis-fat graft. A musculocutaneous flap is advanced over the graft to provide the anterior vascular supply for the free dermis-fat graft. The periorbita and remaining orbital tissue provide the vascular supply posteriorly. This technique eliminates extensive skin grafting and delayed spontaneous healing. Wound healing is rapid and surgical morbidity is minimized. We have used this procedure in three patients with sebaceous gland adenocarcinoma, two patients with severe posttraumatic contracted sockets, and as a palliative procedure in one patient with a fungating choroidal melanoma and widespread metastasis.

Adipose Tissue↗
PubMed1985

Instrumented measurement of anterior laxity of the knee.

We performed instrumented measurement of anterior-posterior laxity of the knee in thirty-three cadaver specimens, 338 normal subjects, and eighty-nine patients with unilateral disruption of the anterior cruciate ligament. The test instrument was the Medmetric knee arthrometer, model KT-2000. We measured total anterior-posterior laxity, produced by anterior and posterior loads of eighty-nine newtons (twenty pounds), and the anterior compliance index. The total anterior-posterior laxity is composed of an anterior displacement and a posterior displacement; these are measured from a testing reference position, defined as the resting position of the knee after applying and then releasing a posterior load of eighty-nine newtons. The anterior compliance index is defined as the anterior displacement between an anterior load of sixty-seven newtons and one of eighty-nine newtons. All tests were performed with the knee held on a thigh support that placed the knee in 20 +/- 5 degrees of flexion. The mean anterior displacement at eighty-nine newtons was 5.7 millimeters in a group of normal subjects and 13.0 millimeters in a group of patients with a disrupted anterior cruciate ligament. Ninety-two per cent of the normal subjects had a left knee-right knee difference in anterior displacement of no more than two millimeters, while 96 per cent of the patients with a unilateral disruption of the anterior cruciate ligament had an injured knee-normal knee difference in anterior displacement of more than two millimeters. Ninety-three per cent of the normal subjects had a difference in the left-right compliance index of no more than 0.5 millimeter, and 85 per cent of the patients with unilateral disruption of the anterior cruciate ligament had a difference in the compliance index of the injured and normal sides of more than 0.5 millimeter.

Adolescent↗
PubMedDate not supplied

The effect of continuous passive motion on anterior cruciate ligament reconstruction stability.

This study was undertaken to examine the immediate effect of continuous passive motion (CPM) on anterior cruciate ligament (ACL) reconstruction stability. Cadaver knees were tested with a knee arthrometer with the anterior cruciate intact and then with the anterior cruciate sectioned. One of three anterior cruciate reconstructions was then performed and stability was restored to the knee and it was again tested with the knee arthrometer. Stability was defined as being within 2 mm of the intact measurement. The three operations selected were the Marshall-MacIntosh "over-the-top," (OTT) a patellar bone-patellar tendon-tubercle bone (BTB) graft, and a semitendinosis reconstruction. The specimens were placed on a CPM device in a cooler at 38 degrees F and put through a range of motion of 20 to 70 degrees at 10 cycles per minute for 3 days. A success was less than a 2 mm increase in the post-CPM measurement compared to pre-CPM. All three bone-tendon-bone operations failed. The semitendinosis operation was successful in only three out of eight specimens. The OTT operation was successful in eight out of nine specimens. The possible reasons for success and failure are discussed. Because of the potential problems with failure of an ACL with CPM it is suggested that the particular technique being used for an anterior cruciate reconstruction be tested prior to it being used with CPM clinically.

Humans↗