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Biomedical subjects

R C Beach

Publications and source records attributed to R C Beach.

At least 19 recordsLinked to original sources
PubMed1986

Determination of lactulose and soya oligosaccharides in infant formula milk feeds.

A paper chromatography technique is described for the separation and quantification of minor sugars in infant formula milks. The precision and reliability of the technique are described. Infant milk feeds of various types were analysed and found to contain up to 11.4 mmol/l of the non-absorbed sugar lactulose. Soya derived feeds may contain a significant residue of non-absorbable oligosaccharides.

Carbohydrates↗
PubMed1984

Gastrointestinal permeability in food-allergic eczematous children.

Gastrointestinal permeability has been studied in a group of clinically proven food-allergic eczematous children and compared with a control group using lactulose and L-rhamnose as probe markers. No significant difference was demonstrated in baseline permeability measurements between eczematous and control children using isotonic or hypertonic oral loading. Similarly after antigen-challenge permeability results showed no significant difference from the controls although two of the ten eczematous children challenged showed increased permeability to lactulose. These findings support the hypothesis that once sensitized the physiological absorption of dietary antigen may be sufficient to maintain an allergic response in the skin.

Animals↗
PubMed1982

Gastrointestinal permeability changes in the preterm neonate.

The lactulose/L-rhamnose urinary excretion ratio during continued infusion of milks containing both sugars was used as an index of the permeability of the neonatal bowel to large and small molecules. Healthy infants of gestational age 31-36 weeks proved to have a period of enhanced permeability to lactulose during the first week of life, the lactulose/L-rhamnose excretion ratio being significantly higher on day 2 than on days 9 or 16 when a mature pattern of permeability could be seen. In infants traumatised by asphyxia or sepsis this change was much less pronounced. Healthy preterm infants of gestational age 26-29 weeks showed a 'mature' pattern of permeability at birth, followed by a temporary period of enhanced permeability after 3-4 weeks of life. It is proposed that enhanced permeability to larger molecules is a specific temporary condition of the neonatal bowel in man as in other mammals, but the immunological implications in man remain to be established.

Digestive System Physiological Phenomena↗
PubMed1981

Lormetazepam - a benzodiazepine derivative without hangover effect? A double-blind study with chronic insomniacs in a general practice setting.

Lormetazepam, a new short-acting benzodiazepine, was tested multicentrally in 15 general practices. The subjects were 62 chronically sleep-disturbed patients. The first 7 days served as a placebo baseline week, the next 14 days were either lormetazepam or placebo in a randomized double-blind design, and during the last week placebo was given again to measure rebound effects. Lormetazepam was found to be an effective hypnotic that causes virtually no hangover the next morning. In this study no rebound effects could be measured. Visual analogue scales, among others, were used for the assessment of sleep characteristics.

Adult↗
PubMed1979

Continuing mortality and morbidity from smallpox vaccination.

Three cases of cross-infection after smallpox vaccination are described, in two of which the outcome was fatal. Probably all occurred because simple precautions were not observed at the time of vaccination--for example, exclusion of contraindications and warnings about risks. If those countries still requiring evidence of vaccination for entry were to abolish this rule, however, the risk of cross-infection could be eliminated. Vaccinating a person with contraindications is justified only when exposure to smallpox has occurred.

Adult↗
PubMed1978

The psychotropic properties of estrogens.

In this review article clinical literature and experimental work from biochemistry, electro-encephalography and experimental psychology will be reported. Like the androgens and progestogens reviewed earlier, estrogens have psychotropic properties comparable to those of well-known psychotropic compounds. These are: improvement of psychological test results and increase in extraversion and decrease in neuroticism according to the Eysenck Personality Model (1964). Such effects are usually associated with the psychostimulants. The immediate effect on EEG of 4 mg estradiol valerate (single oral dose, male subjects), is a standard EEG profile similar to that of the tricyclic antidepressants. High dosages of estrogens have antidepressant properties clinically. In terms of psycho-pharmacological profiles, the estrogens seem to be a new type of psychotropic compound.

Adult↗
PubMed1978

Experimental and clinical data indicating the psychotropic properties of progestogens.

Investigations of the psychotropic effects of progestogens employing the technique of quantitative pharmaco-EEG indicated that progestogens produce a profile similar to that of the minor tranquillizers. Healthy volunteers received single oral doses in a double-blind controlled study. A short review of the clinical literature adds support to the suggestion that progestogens have sedative properties.

Behavior↗