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Biomedical subjects

R C Erickson

Publications and source records attributed to R C Erickson.

14 recordsLinked to original sources
PubMed1979

Cephalosporin derivatives with 2- and 4-pyridone groups at carbon-3.

Two compounds, analogues of cephalexin with 2- and 4-pyridone groups at C-3, were prepared. Biological evaluation found the compounds to exhibit activity against Gram-positive and Gram-negative organisms in vitro and in vivo. The compounds were only active in vivo on subcutaneous administration.

Administration, Oral↗
PubMed1978

Abbreviating the Halstead-Reitan neuropsychological test battery.

Describes a brief and relatively data-rich abbreviated form of the Reitan. By employing the Trail Making Test, the Aphasia Screening Test, and Block Design and Digit Symbol from the WAIS, one can predict the presence and severity of organic impairment and comment on lateralization and localization. Findings are cross-validated.

Adult↗
PubMed1978

Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives.

A series of 1-pyrrole- and 1-indoleacetamido derivatives of 3-heteroaryl-substituted cephalosporins was prepared. The most active compound in the series was 7-[[2-(1-pyrryl)acetyl]amino]-3-[[(1-methyltetrazol-5-yl)thio]-methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6), which showed comparable potency in vitro and in vivo to that of cefazolin, and, in addition, was more potent than cefazolin against Enterobacter sp. and Providencia stuartii.

Animals↗
PubMed1978

Problems in the clinical assessment of memory.

The purpose of this paper is to examine the current state of clinical memory testing in the light of recent theoretical and experimental advances in the study of human memory. It recounts some of the purposes of memory testing and inadequacies in the tests currently available. A brief review of information processing theory and experimental findings with Korsakoff patients and aged normals provides a number of considerations that must be attended to in developing more adequate memory tests in the future.

Aged↗
PubMed1978

The Defense Mechanism Inventory and alcoholics.

The utility of the Defense Mechanism Inventory (DMI) with alcoholic patients was evaluated by reviewing previous research and presenting new data concerning the test characteristics and the relationships between the DMI and various demographic, cognitive, and personality variables. In general, the defense mechansims of projection and turning against others was associated with greater anxiety, depression, and psychopathology. Utilization of the mechanisms of intellectualization and denial were related to lower levels of psychopathology. The construct validity of the DMI was questioned in view of the results obtained, and the utility of the measure for the prediction of treatment response of alcholics was discussed.

Alcoholism↗
PubMed1977

Using the MMPI 168 with alcoholics.

The potential utility of the MMPI 168 with male alcoholics was explored. Correlations and some clinically relevant comparisons suggested that the MMPI 168 predicted the standard MMPI with a high degree of accuracy. However, high point codes and conclusions drawn from Goldberg's equations were not so promising, which suggests the need to establish the relative validity of the MMPI 168 by the use of external criteria.

Adult↗
PubMed1977

Brain damage and five MMPI items with alcoholic patients.

The validity of Hovey's brain damage MMPI index for male alcoholic inpatients was investigated. With educational level controlled, the scale did not show significant relationships with established tests of cognitive and organic impairment. Significant correlations were found with measures of psychopathology. This suggests that only in populations in which neurological deficit is the main factor in variations in emotional and physical well-being will this type of index be useful to screen patients for brain damage. The results stress the importance of local cross-validation prior to the clinical use of measures such as Hovey's scale.

Adult↗
PubMed1976

Fatal vaccine-induced canine distemper virus infection in black-footed ferrets.

Four black-footed ferrets that were live-trapped in South Dakota and transported to the Patuxent Wildlife Research Center died within 21 days after vaccination with modified live canine distemper virus. Immunofluorescence, European ferret inoculation, virus isolation attempts, and serum-neutralization tests indicated insufficient attenuation of the vaccine for this species.

Animals↗
PubMed1976

Using the MMPI 168 with medical inpatients.

The potential utility of the MMPI 168 with two inpatient medical populations was explored in the present study. Correlations and clinically relevant comparisons suggested that the MMPI 168 predicted the standard MMPI with a high degree of accuracy.

Adult↗