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Biomedical subjects

R C Franz

Publications and source records attributed to R C Franz.

At least 19 recordsLinked to original sources
PubMed1996

Sigmoid colon vaginoplasty: a modified method.

OBJECTIVE: To assess the technical feasibility and functional results of sigmoid colon vaginoplasty using a modified technique. DESIGN: Retrospective descriptive analysis. SETTING: Referral centre. PATIENTS: A method for creating an artificial vagina was applied in 13 women for the following indications: true hermaphrodite (n = 1), gender dysphoria (n = 2), Müllerian dysgenesis (n = 10). INTERVENTIONS: A method for sigmoid vaginoplasty was devised whereby transection of the inferior mesenteric artery proximal to the first sigmoid branch provides immediate mobility for the sigmoid colonic segment to reach the introitus (with adequate nourishment from the middle and inferior rectal vascular systems). MAIN OUTCOME MEASURES: Assessment of sexual function after a follow up period of 1 to 19 years. RESULTS: Twelve women reported a satisfactory result. Three of these were lost to follow up after one year, and the others report for regular assessment. Mild stenosis at the muco-cutaneous anastomosis, which may occur after failed perineal procedures, appears to be amenable to daily dilatations until the women become sexually active. In one woman the prosthesis had to be removed on account of severe pelvic floor fibrosis as a result of previous abdomino-perineal surgery at the age of seven. Another woman presented with a postcoital vesico-vaginal fistula after a previous McIndoe procedure; the tear at the base of the bladder was repaired and buttressed with a sigmoid vagina which is now functioning satisfactorily after 19 years. CONCLUSION: The creation of a sigmoid vagina which is vascularised by the middle and inferior rectal arterial systems appears to be an acceptable procedure for vaginal agenesis, acquired vaginal loss or sexual reassignment.

Adolescent↗
PubMed1992

The effect of calcium and magnesium ions on urinary urokinase and sialidase activity.

The effect of a promoter (calcium) and an inhibitor (magnesium) of urolithiasis was spectrophotometrically studied on urokinase (0.45 IU) and sialidase (5 mM). Although these mineral did not affect the sialidase activity, total inhibition of urokinase activity was observed with either 0.05 M calcium chloride or 0.1 M magnesium chloride. This observation might explain why calcium and magnesium respectively function as a promoter and an inhibitor of stone formation.

Calcium↗
PubMed1987

Acute acalculous cholecystitis in critically ill patients. Case reports.

Five cases of acute acalculous cholecystitis complicating trauma or an existing major illness are reviewed. This condition differs from classical cholecystitis in many aspects. It is serious and often fatal (3 of our patients died) with multifactorial pathogenesis. Clinical signs and laboratory investigations may be difficult to interpret because of associated conditions. Serial ultrasound examinations in high-risk patients in whom the disease is suspected should lead to earlier diagnosis. Early cholecystectomy is mandatory.

Acute Disease↗
PubMed1987

Baboon (Papio ursinus) model to study deep vein thrombosis using 111-indium-labeled autologous platelets.

This study evaluates the chacma baboon as a model for investigations on deep vein thrombosis (DVT). There is a good correlation of the baboon and human thrombelastographic parameters (r-time, k-time, ma). Investigation on the diagnostic efficacy of 111 In-labeled platelets as an imaging agent for DVT cast considerable doubt on the procedure, owing to the age of the thrombus.

Animals↗
PubMed1985

Evaluation of the diagnostic efficacy of autologous 111In-labelled platelets as a scanning agent for deep vein thrombosis in the chacma baboon.

The diagnostic efficiency of autologous 111In-labelled platelets (ILP) as a scanning agent in deep vein thrombosis (DVT) was investigated in 24 South African baboons (Papio ursinus). Thrombi were surgically induced by stasis, intimal injury and the injection of thrombin in the common femoral veins of adult baboons. The thrombi were allowed to age for 1, 2, 4, 8, 24, 48 and 72 h before injecting the ILP. Scanning was done with a large field gamma camera at 10 min post injection and again at 2, 4, 6, 8, 10, 14, 24, 48 and 72 h. Time-activity curves were thus obtained and it was possible to establish an optimal time after injection of the ILP to scan for each group of thrombi. The results indicate that only the younger thrombi (1-8 h after thrombus formation) were detected. Twenty-four hour and older thrombi were not visualised. A favourable time to scan in the case of the younger thrombi appeared to be approximately 20 h after the injection of ILP. However, the thrombus age limitation still impairs the diagnostic efficiency of the procedure.

Animals↗