Biomedical subjects

R C Grace

Publications and source records attributed to R C Grace.

7 recordsLinked to original sources

PubMed2001

Lipid induced conformation of the tachykinin peptide Kassinin.

Both the aqueous and lipid-induced structure of Kassinin, a dodecapeptide of amphibian origin, has been studied by two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy and distance geometry calculations. Unambiguous NMR assignments of protons have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The distance constraints obtained from the NMR data have been utilized in a distance geometry algorithm to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that, while in water Kassinin prefers to be in an extended chain conformation, in the presence of perdeuterated dodecylphosphocholine (DPC) micelles, a membrane model system, helical conformation is induced in the central core and C-terminal region (K4-M12) of the peptide. N-terminus though less defined also displays some degree of order and a possible turn structure. The conformation adopted by Kassinin in the presence of DPC micelles is consistent with the structural motif typical of neurokinin-1 selective agonists and with that reported for Eledoisin in hydrophobic environment.

Circular Dichroism↗

PubMed2000

Behavioral momentum and the law of effect.

In the metaphor of behavioral momentum, the rate of a free operant in the presence of a discriminative stimulus is analogous to the velocity of a moving body, and resistance to change measures an aspect of behavior that is analogous to its inertial mass. An extension of the metaphor suggests that preference measures an analog to the gravitational mass of that body. The independent functions relating resistance to change and preference to the conditions of reinforcement may be construed as convergent measures of a single construct, analogous to physical mass, that represents the effects of a history of exposure to the signaled conditions of reinforcement and that unifies the traditionally separate notions of the strength of learning and the value of incentives. Research guided by the momentum metaphor encompasses the effects of reinforcement on response rate, resistance to change, and preference and has implications for clinical interventions, drug addiction, and self-control. In addition, its principles can be seen as a modern, quantitative version of Thorndike's (1911) Law of Effect, providing a new perspective on some of the challenges to his postulation of strengthening by reinforcement.

Behavior↗

PubMed2000

Temporal context and conditioned reinforcement value.

The effectiveness of a stimulus as a conditioned reinforcer depends on the temporal context of reinforcement, that is, the overall rate of reinforcement in the situation. The dominant view has been that context determines the learned value of a stimulus directly, according to delay-reduction theory. By contrast, the contextual choice model (CCM) maintains that value is independent of context and incorporates the effects of context on choice in the framework of the matching law. The authors report 2 experiments with pigeons as subjects that use transfer tests to assess the value of stimuli in the concurrent-chains procedure. Results strongly support the assumption of CCM that pigeons learn the temporal relations between events independently of context but that context modulates the expression of that learning as choice.

Animals↗

PubMed2000

The relationship between value and temporal context is an empirical question: a reply to Fantino (2000).

E. Fantino (2000) argued that R. C. Grace and H. I. Savastano's (2000) experiments fail to elucidate the relationship between stimulus value and temporal context. His reasoning is that predictions for R. C. Grace and H. I. Savastano's probe tests based on delay-reduction theory (DRT) and the contextual choice model (CCM) are indistinguishable. However, his method of applying DRT to the probes ensures that temporal context will have no effect on which stimulus is preferred, contrary to the core principle of that theory. The only basis for differential responding in the probes is baseline training, and R. C. Grace and H. I. Savastano's data clearly show that the terminal-link schedules, independent of temporal context, control choice in the probes, as predicted by CCM.

Animals↗

PubMed2000

Comparing preference and resistance to change in constant- and variable-duration schedule components.

Two experiments explored preference and resistance to change in concurrent chains in which the terminal links were variable-interval schedules that ended either after a single reinforcer had been delivered (variable duration) or after a fixed period of access to the schedule (constant duration). In Experiment 1, pigeons' preference between the same pair of terminal links overmatched relative reinforcement rate when the terminal links were of constant duration, but not when they were of variable duration. Responding during the richer terminal link decreased less, relative to baseline, when response-independent food was presented during the initial links according to a variable-time schedule. In Experiment 2, all subjects consistently preferred a terminal link that consisted of 20-s access to a variable-interval 20-s schedule over a terminal link that ended after one reinforcer had been delivered by the same schedule. Results of resistance-to-change tests corresponded to preference, as responding during the constant-duration terminal link decreased less, relative to baseline, when disrupted by both response-independent food during the initial links and prefeeding. Overall, these data extend the general covariation of preference and resistance to change seen in previous studies. However, they suggest that reinforcement numerosity, including variability in the number of reinforcers per terminal-link entry, may sometimes affect preference and resistance to change in ways that are difficult to explain in terms of current models.

Animals↗

PubMed2000

Preference and resistance to change with constant-duration schedule components.

Previous research on preference between variable-interval terminal links in concurrent chains has most often used variable-duration terminal links ending with a single reinforcer. By contrast, most research on resistance to change in multiple schedules has used constant-duration components that include variable numbers of reinforcers in each presentation. Grace and Nevin (1997) examined both preference and resistance in variable-duration components; here, preference and resistance were examined in constant-duration components. Reinforcer rates were varied across eight conditions, and a generalized-matching-law analysis showed that initial-link preference strongly over-matched terminal-link reinforcer ratios. In multiple schedules, baseline response rates were unaffected by reinforcer rates, but resistance to intercomponent food, to extinction, and to intercomponent food plus extinction was greater in the richer component. The between-component difference in resistance to change exhibited additive effects for the three resistance tests, and was systematically related to reinforcer ratios. However, resistance was less sensitive to reinforcer ratios than was preference. Resistance to intercomponent food and to intercomponent food plus extinction was more sensitive to reinforcer ratios in the present study than in Grace and Nevin (1997). Thus, relative to variable-duration components, constant-duration components increased the sensitivity of both preference and relative resistance, supporting the proposition that these are independent and convergent measures of the effects of a history of reinforcement.

Animals↗

PubMed1999

Does the context of reinforcement affect resistance to change?

Eight pigeons were trained on multiple schedules of reinforcement where pairs of components alternated in blocks on different keys to define 2 local contexts. On 1 key, components arranged 160 and 40 reinforcers/hr; on the other, components arranged 40 and 10 reinforcers/hr. Response rates in the 40/hr component were higher in the latter pair. Within pairs, resistance to prefeeding and resistance to extinction were generally greater in the richer component. The two 40/hr components did not differ in resistance to prefeeding, but the 40/hr component that alternated with 10/hr was more resistant to extinction. This discrepancy was interpreted by an algebraic model relating response strength to component reinforcer rate, including generalization decrement. According to this model, strength is independent of context, consistent with research on schedule preference.

Animals↗