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Biomedical subjects

R C Kline

Publications and source records attributed to R C Kline.

30 records · Page 2Linked to original sources
PubMed1987

Ureteral assessment after radical hysterectomy.

Postoperative intravenous pyelography was performed in 233 patients with stage IB cervical carcinoma treated with radical hysterectomy and pelvic lymphadenectomy between January 1962 and December 1985. Four patients developed symptoms of ureteral injury, two (0.8%) ureteral fistulae, and one (0.4%) stricture and obstruction due to recurrent carcinoma. No ureteral injuries were observed in 229 asymptomatic patients. A 5.2% incidence of transient severe ureteral dilatation occurred in asymptomatic patients, but resolved within a median of 94 days. A significant urinary tract anomaly was observed in 3.4% of preoperative pyelograms. All of these anomalies were apparent at surgery and presented no intraoperative difficulties. Three patients (1.3%) sustained intraoperative ureteral transections, which were diagnosed and repaired without sequelae. In patients with early cervical carcinoma having primary operative treatment, the role of routine preoperative and postoperative intravenous pyelography is questionable.

Adult↗
PubMed1986

Chemotherapeutic complete remission in patients with metastatic ovarian dysgerminoma. Potential for cure and preservation of reproductive capacity.

Two patients with metastatic dysgerminoma of the ovary were treated with a combination of etoposide, bleomycin, and cisplatin at The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston. Both patients achieved a complete remission. Patient 1 developed a massive recurrence in the para-aortic lymph nodes 21 months after diagnosis and treatment with right salpingo-oophorectomy alone. She received four cycles of chemotherapy and is free of disease 21 months from the start of chemotherapy. Patient 2 had Stage III dysgerminoma and a lymphangiogram positive for tumor in the para-aortic lymph nodes. After surgery she received three cycles of chemotherapy and is free of disease 20 months from the start of chemotherapy. Both complete remissions were documented with second-look laparotomy. Chemotherapy may be an alternative to radiotherapy for the treatment of metastatic dysgerminoma and should also be considered for selected patients with Stage I disease. A literature review further supports the conclusion that additional clinical trials might expand the indications for chemotherapy in patients with this disease.

Adolescent↗
PubMed1981

Thallium-201 myocardial scintigraphy: a critical comparison of seven-pinhole tomography and conventional planar imaging.

Seven-pinhole tomographic and planar thallium-201 imaging was performed on 63 consecutive patients to assess the clinical value of these techniques. Significant coronary artery disease (stenosis greater than or equal to 70%) was present in 52 patients. Comparing the seven-pinhole results with those of the planar, the findings for sensitivity, specificity, and inter- and intraobserver agreement were, respectively, 94% against 75% (p less than 0.005), 91% against 91%, 86% against 79%, and 97% against 92%. In 25 patients in this group with a prior myocardial infarction, sensitivity was 100% for tomographic imaging and 92% for planar. In 27 patients without prior myocardial infarction, by contrast, sensitivity for tomographic imaging was 89% and for planar imaging 59% (p less than 0.01). Thus we conclude that both tomographic and planar imaging are highly sensitive for the detection of significant coronary artery disease, but tomographic imaging is significantly more sensitive in patients without prior myocardial infarction.

Coronary Disease↗
PubMed1981

Tomographic thyroid scintigraphy: comparison with standard pinhole imaging: concise communication.

Coded-aperture imaging (CAI) and multiple-view pinhole imaging (PI) of the thyroid were compared in a prospective study in 136 consecutive patients. Following 10 mCi of pertechnetate, 200K-count pinhole images were obtained in the anterior, RAO, and LAO projections, and CAI data were obtained in the anterior position. Four coronal tomographic sections were reconstructed by computer. Five observers read the studies separately, and ROC curves were constructed. Based on 109 pairs of studies, the ROC curves revealed similar performance for all observers for both techniques. When four observers compared the studies subjectively they rated the CAI more useful in 36% of cases, the PI in 6%, and the two equal in 58%. The advantages offered by the tomograms included improved contrast, accurate size representation of the gland at all depths, freedom frm pinhole-type distortion, and faster data acquisition. The major disadvantage to tomography was the 2-hr computer-processing time required. It this can be reduced, CAI offers sufficient advantages over conventional pinhole imaging to warrant its routine use.

Adult↗
PubMed1981

Myocardial imaging in man with I-123 meta-iodobenzylguanidine.

Meta-[123I]iodobenzylguanidine (m-[123I]IBG), a guanethidine analog, was used to image the myocardium in five normal male volunteers. Each subject received 2.0 mCi m-[123I]IBG intravenously. Four were given a bolus injection. Multiple myocardial scintigrams were obtained over a 2-hr period. Myocardial uptake was calculated by dividing the decay-corrected global myocardial count rate (after interpolated background correction) by the peak count rate during the first passage of the m-[123I]IBG bolus through the heart. The left ventricle could be visualized within 1-2 min of m-[123I]IBG injection. Mean myocardial uptake was 0.63% (range 0.45-0.78%) of injected dose at 5 min, and 0.76% (range 0.49-0.93%) at 2 hr (n = 4). m-[123I]IBG may provide quantitative information on myocardial catecholamine content.

3-Iodobenzylguanidine↗
PubMedDate not supplied

Comparison of observer performance reading from a video CRT vs. reading from film.

The developing trend for all medical images to be in digital form raises an important question: should diagnostic interpretations be made directly from a CRT or from some form of hard copy recording of the CRT? This question was studied by having two observers read a series of digital images of the thyroid including both conventional scintigrams and computer-generated tomograms. The CRT images were photographed in a carefully controlled fashion. Images were read once from film and a second time directly from the CRT. No significant difference in performance could be found for either display modality based on an ROC analysis. Although based on uncomplicated images and analysis, this result suggests that the decision to read from film or from the CRT can be made on other grounds than observer performance. This important result needs confirmation with more complex images such as ultrasound or CT.

Data Display↗