Biomedical subjects

R C Lewis

Publications and source records attributed to R C Lewis.

45 records · Page 3Linked to original sources

PubMed1981

Control of severe hypertension with pulse diazoxide.

Immediate or rapid reduction in blood pressure may be indicated in the management of hypertensive emergencies in patients with recognized cardiovascular or cerebrovascular disease. Our study has shown that pulse administration of diazoxide is effective in reducing blood pressure in these patients with severe, uncontrolled hypertension. Blood pressure reduction was gradual and could be titrated with repeated pulses of 50 or 75 mg of diazoxide. Pulse administration of diazoxide may represent the preferred method of administration in most patients when this potent antipressor agent is indicated. Our experience suggests that pulse diazoxide appears to be a suitable alternative to other parenteral antihypertensive agents and provides a gradual reduction of blood pressure in high-risk patients with severe, uncontrolled hypertension. The procedure carries a minimum risk of serious cardiovascular sequelae.

Adult↗

PubMed1980

Cerebellar astrocytoma invading the musculature and soft tissues of the neck. Case report.

A case of cerebellar astrocytoma with unusual growth pattern in an 8-year-old boy is reported. The tumor had some histological hallmarks of malignancy (focally high cellularity, mitotic figures, necroses, and calcifications) and, 17 months after subtotal removal, recurred as a nuchal mass in the area of the incision, infiltrating first the skeletal musculature and later other soft tissues of the neck, including lymph nodes. Although cerebellar astrocytomas may recur locally and some may even seed through the cerebrospinal fluid, this is the first reported case of a tumor of this group to infiltrate skeletal muscle and other soft tissues of the neck. The patient underwent five operations to relieve the cervical organs from pressure.

Astrocytoma↗

PubMed1980

HDL-cholesterol concentration and severity of coronary atherosclerosis determined by cine-angiography.

We studied 226 adult male subjects (mean=52yr) who underwent coronary arteriography. Their serum lipid and lipoprotein levels [total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), LDL-C, HDL-phospholipid (HDL-P), HDL-TG, HDL-C/TC, HDL-P/TC, LDL-C/TC, LDL-C/HDL-C and LDL-C/HDL-P] were correlated with the severity of coronary artery disease (CAD). Studies showed a slight but statistically significant correlation (linear regression) between CAD and HDL-P/TC (r=-0.24, P < 0.001), HDL-C/TC (r=-0.20, P < 0.002), followed by LDL-C/HDL-P (r=0.19, P < 0.004) and HDL-P (r=-0.18, P < 0.008). HDL-C, LDL-C and TC were significant at the P < 0.05 level; P value of TG was non-significant. Subjects were conveniently grouped based on degree of coronary artery narrowing: normal, mild (1-50%); moderate-severe (51-99%) and very severe (100% occlusion). Of the 11 lipid variables, the best predictor of the stage of the CAD was HDL-P/TC as measured by one-way analysis of variance. This trend was unaltered even after adjustment for covariates. HDL-P, LDL-C/HDL-P and HDL-C/TC were also significant, but the other lipid parameters were not. The study indicates that HDL-C, by itself, is not as effective a predictor of CAD as HDL-P/TC. Also, the small but statistically significant inverse relationship between HDL-P/TC and CAD suggests that a low HDL-P/TC ratio can be considered a risk factor for CAD but not as a dependable clinical diagnostic aid for predicting the severity of CAD on an individual basis.

Adult↗

PubMed1979