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Biomedical subjects

R C Mahapatro

Publications and source records attributed to R C Mahapatro.

6 recordsLinked to original sources
PubMed1984

Cutaneous basophil hypersensitivity.

Cutaneous basophil hypersensitivity is a distinct form of hypersensitivity reaction with a delayed-time course that is different from both the classic delayed-type hypersensitivity reaction and immediate hypersensitivity reaction. It occurs in humans, guinea pigs, and other animals. It may be induced by sensitization with a variety of antigens (viruses, allografts, parasites, fungal antigens, etc.) in incomplete Freund's adjuvant and elicited by skin testing 7 days later with the specific antigens. The cutaneous reaction in basophil hypersensitivity is characterized clinically by less indurated erythema than in classic delayed hypersensitivity, and microscopically by numerous basophils in the papillary dermis. The reaction is mediated by both T- and B-lymphocytes. A basophil chemotactic factor as a mediator of the reaction has also been identified. The reaction may be inhibited by Fc fragments. Basophils on arrival at the local site may degranulate and the released vasoamine may have protective or regulatory effects depending on particular circumstances.

Animals↗
PubMed1979

Numbers of mast cells in the axillary lymph nodes of breast cancer patients.

This retrospective study of surgical specimens from forty-three consecutive patients treated by modified radical mastectomy for carcinoma of the breast shows that those patients surviving for at least sixty months after operation have a significantly greater number of mast cells in their axillary lymph nodes than the nonsurvivors (p less than .001). When expressed as cells/mm2 the survivors are associated with nodal concentrations greater than eleven mast cells per square millimeter while the nonsurvivors haver fewer than eleven mast cells/mm2. The results suggest that the number of nodal mast cells may be a readily quantitated host response of prognostic value in carcinoma of the breast.

Adult↗
PubMed1979

Distribution of mast cells in the axillary lymph nodes of breast cancer patients.

In a study of the pattern of distribution of mast cells in the axillary lymph nodes of 43 consecutive breast cancer patients it was observed that: 1) the pattern of distribution of mast cells in the survivors and nonsurvivors is similar, 2) there is almost complete absence of mast cells in the germinal centers with predominance of them in the T cell areas, and 3) a significant number of mast cells are seen in the afferent lymphatic route and the highest percentages of mast cells found in the medullary sinuses. The significance of these findings as they pertain to the relation of mast cells to the T cell system and to the migratory nature of mast cells is discussed.

B-Lymphocytes↗