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R C Meagher

Publications and source records attributed to R C Meagher.

22 records · Page 2Linked to original sources
PubMed1980

Studies on the anemia of the Shay chloroleukemia.

The pathogenesis of the anemia which occurs in rats bearing the Shay chloroleukemia (SCL) was investigated. Severe anemia, shown not to result from hemodilution, developed in the terminal stage of the disease. The rapid progression of the anemia suggested that reduced erythropoiesis was of no more than minor importance in the development of this anomaly. No evidence for a major hemolytic event was observed. Data are presented which suggest that hemostatic defects may be primarily responsible for the anemia of SCL. Because of many similarities with the pathogenesis of human myelogenous leukemia, SCL is proposed as a useful model for further studies on interreactions between the leukemic environment and the erythrocyte population.

Anemia↗
PubMed1978

Chromosomal evidence for the transplantability of the Shay chloroleukemia.

Chloroma cells, which were shown to contain the X and Y chromosomes, were used to induce Shay chloroleukemia (SCL) in female recipients. Karyotype analyses of leukemic myeloblasts which appeared in the peripheral blood of the female recipients during blast crisis demonstrated invariably the presence of the X and Y chromosomes. These results directly demonstrate that transmission of SCL is the result of donor cell colonization and therefore SCL can be considered a true transplantable leukemia. Reports by other workers of viral association with this disease are discussed in light of our results.

Animals↗
PubMedDate not supplied

Thymus-conditioned medium influences in vitro colony formation by hematopoietic progenitor cells.

Medium conditioned by mouse thymic cells cultured for 7 days in the presence of concanavalin A (Con A) and 5% human serum enhanced erythroid colony formation by CFU-E but not BFU-E. Medium conditioned by thymic cells for less than 7 days or more than 7 days inhibited erythroid colony formation. Enhancement of erythroid colony formation occurred at both suboptimal and saturating concentrations of erythropoietin. The thymus-conditioned medium also stimulated the growth of granulocyte/macrophage colonies by itself and in the presence of a saturating concentration of WEHI-3 conditioned medium. The conditioned medium contained neither burst-promoting activity nor erythropoietin. The erythroid colony-enhancing activity in the thymus-conditioned medium was heat stable, bound to immobilized Con A, lacked protease activity and migrated with an approximate molecular weight of 68,000 on gel filtration.

Animals↗