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Biomedical subjects

R C Misra

Publications and source records attributed to R C Misra.

At least 19 recordsLinked to original sources
PubMed1991

High prevalence & heterogenicity of thalassaemias in Orissa.

High incidence of alpha thalassaemias (estimated from detection of Hb Bart's from cord blood), Hb constant spring (CS) and high A2 beta thalassaemia trait (estimated from normal adult subjects) were detected in 12.6, 15 and 8 per cent people of coastal Orissa (with less than 5% tribal population) respectively. Quantitation of Hb Bart's suggest that the alpha thalassaemia could be any of the genotypes such as, -alpha/alpha alpha, -alpha/-alpha, --/alpha alpha and alpha alpha/alpha alpha cs. Both heterozygotes and homozygotes for Hb CS were identified.

Fetal Blood↗
PubMed1991

Transferrin saturation studies in male adults showing high prevalence of iron deficiency.

Estimation of serum iron, total iron binding capacity (TIBC) and transferrin saturation was performed in 62 apparently healthy male medical students. All had haemoglobin over 140 g/1. Low serum iron, elevated level of TIBC and transferrin saturation under 20% indicating iron deficiency state was found in 2 subjects. Elevated values of TIBC was found in 25 (40.32%) students as evidence of latent iron deficiency. Such high prevalence of iron deficiency in an affluent group indicates widespread iron deficiency in the general population.

Adult↗
PubMed1989

Detection of alpha thalassaemia in sickle cell trait patients by Hb-Bart's screening & quantitation of Hb-A & Hb-S.

Haemoglobin fractionation in 27 subjects with sickle cell trait revealed 12 (44%) with sickle cell haemoglobin less than 35 per cent (23.4-34.2%, mean 30.4 +/- 3.3%) suggesting an association of alpha thalassaemia. Electrophoresis of 91 samples of cord blood revealed demonstrable amounts of haemoglobin Bart's in 7 (7.7%); six between 5 and 10 per cent and one with less than 2 per cent. It appeared that the six infants with higher amounts of haemoglobin Bart's were homozygous for alpha-thalassaemia + (-a/-a) genotypes and one was heterozygous for alpha-thalassaemia + (-a/aa) Results of haemoglobin electrophoresis done on 2754 blood samples analysed from hospital records, retrospectively did not reveal haemoglobin-H and haemoglobin Constant Spring in any of the samples.

Anemia, Sickle Cell↗
PubMed1983

Low flow (cryptic) arteriovenous malformation and spontaneous haematoma.

The authors emphasize the meticulous search for microangioma under magnification in cases of spontaneous haematoma. Two cases of low flow (cryptic) arteriovenous malformations are described. The CT scan and angiography are non-contributory in detecting such lesions. These small-sized angiomas are buried in the wall of the haematoma cavity. Histologically there is evidence of thrombosis in arteriovenous malformation.

Adult↗
PubMed1982

Gastric tuberculosis.

A 63-year-old female presented with upper epigastric pain. On endoscopy a giant gastric ulcer was observed on the lesser curvature of the stomach. Biopsies taken from the ulcer showed epitheloid cell granulomas with caseation, suggesting a diagnosis of granulomatous gastritis probably tubercular in origin. No AFB was seen in the biopsied material, the culture also failed to grow AFB. Radiograph of the chest was normal. On anti-tubercular treatment the patient showed remarkable recovery and the ulcer healed completely following 3 1/2 months of treatment.

Female↗