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Biomedical subjects

R C Parish

Publications and source records attributed to R C Parish.

At least 37 records · Page 2Linked to original sources
PubMed1985

Seizures following oral lidocaine for esophageal anesthesia.

Lidocaine is absorbed from mucous membranes of the oropharynx, gastrointestinal tract, and tracheobronchial tree. First-pass hepatic metabolism of the drug greatly reduces the amount reaching the general systemic circulation in the normal individual. In patients whose hepatic metabolism is reduced by disease or drugs, or in whom liver blood flow is reduced, this first-pass effect is decreased and lidocaine concentrations may be higher than those produced by the same dose in normal patients. We report an elderly man taking cimetidine with congestive heart failure in whom the accidental ingestion of lidocaine solution for esophageal anesthesia was followed by seizures and elevated serum lidocaine concentrations.

Aged↗
PubMed1985

Effect of diet particle size and feeding of H2-receptor antagonists on gastric ulcers in swine.

Four experiments were conducted to evaluate the effect of diet and the administration of H2-antagonists in feed on gastric ulcer formation and performance of growing-finishing swine. Pigs receiving a finely ground diet (less than lmm) grew faster (.73 vs .68 kg/d, P less than .01) and had better feed utilization (3.47 vs 3.76, P less than .01) than pigs receiving a cracked corn-based diet. Incidence of ulcers in the esophageal region of the stomach of pigs fed the finely ground diet was greater (P less than .01) than in pigs fed cracked corn. The average daily gain of pigs receiving the finely ground diet was inversely related to ulcer incidence (r = .403, P less than .01, df = 59). The addition of 5, 10, 20 or 100 ppm of the H2-antagonist, metiamide, or 6, 18 or 54 ppm of SK&F 93479 to the finely ground diet did not improve pig performance or affect the incidence of gastric ulceration. The addition of 2, 6 and 18 ppm of SK&F 93479 to a corn-soy diet containing 4.5% alfalfa meal caused a reduction in gastric ulceration (P less than .05) and improved feed utilization by 3.2% (P less than .05). These data suggest that finely ground diets improve the performance of growing-finishing swine, but increase the incidence of ulcers in the esophageal region of the stomach. Severe gastric ulceration adversely affects swine performance. Feeding H2-antagonists does not reduce the ulcerogenic properties of finely ground diets, suggesting factors other than gastric acid secretion are involved in ulcerogenesis. The use of H2-antagonists in corn-soy diets improves feed utilization and reduces ulceration.

Animal Feed↗
PubMed1983

Effects of diaryliodonium chemicals on rumen fermentation in vitro and in vivo.

In vitro fermentation studies demonstrated that diaryliodonium chemicals were inhibitors of amino acid utilization. Only small differences were found in comparative effectiveness of different analogs and salt forms of chemicals tested. Protection against degradation and(or) uptake was greatest for valine, methionine, isoleucine, leucine and phenylalanine. Although changes were not as large, animals fed 4,4'-dimethyldiphenyliodonium chloride for 112 d had higher ruminal concentrations of amino acids and lower concentrations of ammonia. Decreased production of acetate in conjunction with increased production of propionate and butyrate resulted in improved fermentation efficiencies. Fermentative shifts in vivo were not as large as those observed in vitro and additional investigations are needed to determine whether feeding diaryliodonium chemicals increases the transfer of energy in digested carbohydrates to volatile fatty acids.

Amino Acids↗
PubMed1983

Effects of diaryliodonium chemicals on nitrogen utilization in growing steers.

Diaryliodonium chemicals increased nitrogen (N) absorption, utilization of absorbed N and N retention in growing steers. Fifty parts per million of the chemicals (diphenyliodonium chloride, diphenyliodonium bromide, 4,4'-difluorodiphenyliodonium chloride or 4,4'-dimethyldiphenyliodonium chloride) in the diet appeared sufficient to promote significant (P less than .05 or .10) improvements in N utilization. Diet digestibility was either not affected or improved slightly. We suggest that diaryliodonium chemicals improve N utilization by adjusting the ruminal degradation of dietary protein to yield more amino-N and less ammonia-N.

Animals↗
PubMed1983

Effects of 4,4'-dimethyldiphenyliodonium chloride on performance of growing cattle.

Two 112-d studies were conducted to evaluate effects of the deaminase inhibitor, 4,4'-dimethyldiphenyliodonium chloride, on performance of growing cattle. With diets containing low levels of crude protein (i.e., 11%), 25 ppm of chemical in the diet increased (P less than .05) gain and improved (P less than .05) feed efficiency. Feed intake was not affected. Higher levels of chemical (50 and 100 ppm) produced equivalent responses. With a higher level of dietary crude protein (i.e., 14%) gain and feed efficiency were not improved and some decreases in feed intake were observed. Performance responses resulting from adjustments in ruminal nitrogen transactions to provide more alpha-amino-N depend upon whether the animal needs additional amino acids for maintenance and production. Our data demonstrated that the supply of amino acids can be increased either by adjustment of ruminal nitrogen transactions with a chemical agent or by increasing concentration of dietary protein.

Animals↗
PubMed1981

Albendazole : a comparison of relay embryotoxicity with embryotoxicity of individual metabolites.

By using an experimental model compound (Albendazole, an anthelmintic) the authors compared two methodologies for the toxicological evaluation of bovine hepatic residues. Toxicity was not demonstrated for bovine hepatic residues in a relay embryotoxicity study in the rat. On the other hand, both albendazole and its sulfoxide metabolite produce embryotoxic effects in this rat model. These different results are discussed and explained by considerations related to the no effect levels and the chemical nature of the different types of residues.

Abnormalities, Drug-Induced↗
PubMed1976

Synthesis of 1- and 2-substituted indazoles as anthelmintic agents.

Selective synthesis of 1- and 2-acyl-, alkoxycarbonyl-, and carbamoylindazoles are described. Spectroscopic data which were the basis for structural assignments are presented. These compounds, particularly methyl 2H-indazole-2-carboxylate and N-heptyl-N-methyl-2H-indazole-2-carboxamide, lack the spectrum of anthelmintic activity of the benzimidazole and benzotriazole anthelmintics to which they are structurally related.

Animals↗