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Biomedical subjects

R C Reynolds

Publications and source records attributed to R C Reynolds.

At least 73 records · Page 4Linked to original sources
PubMed1982

Comparison of genetic and endocrine control of renin and kallikrein in mouse submandibular gland.

The effects of strain, sex, hypophysectomy and hormone treatment on mouse submandibular gland renin, kallikrein, S2266 hydrolase, and BAEe esterase activities have been examined. Renin activity is determined by the Rnr locus on mouse Chromosome 1. Female SWR/J mice (Rnrs/Rnrs) have 1000-fold higher submandibular gland renin activity than C57BL/6J mice (Rnrb/Rnrb). Both strains have similar kallikrein activity. Renin, BAEe esterase, and S2266 hydrolase are substantially higher in male mice compared to females of the same strain whereas kallikrein is not. Dihydrotestosterone and/or thyroxine treatment induces renin, BAEe esterase, and S2266 hydrolase in female mice with little effect on kallikrein. All four enzyme activities are profoundly reduced by hypophysectomy. Dihydrotestosterone and thyroxine are both required to restore renin, BAEe esterase, and S2266 hydrolase to induce levels. Dihydrotestosterone and/or thyroxine restores kallikrein to control levels. We conclude that renin and kallikrein in the mouse submandibular gland are under different genetic and endocrine control. In addition, the synthetic substrate S2266 is not a specific substrate for kallikrein activity in mouse submandibular gland cytosol.

Animals↗
PubMed1981

Planning a medical school teaching hospital in an era of cost containment. The CMDNJ-Rutgers Medical School experience.

Rutgers Medical School was started in 1962 as a two year medical school. By 1976 its basic science enrollment had grown to 108 and it retained 56 students each year for clinical instruction. During the early 1970's the medical school had been frustrated on three different occasions in its attempts to build an on-campus teaching hospital. This paper describes the school's successful post-1976 planning efforts to provides its faculty and students with the appropriate clinical facilities by a model which would generate support among external constituencies. The history of the medical school prior to 1976 is presented briefly. The paper then develops the rationale for the new planning model and shows the relationship of the model to the educational bases of the institution. It then tracks the planning process from program development through approvals by the external constituencies and brings the school's experience to the present where ¿ million dollars of construction is under contract for health care delivery and medical education facilities.

Hospital Planning↗
PubMed1981

Management of malignant hyperthermia.

A case of malignant hyperthermia in a young girl with vesicoureteral reflux and multiple congenital abnormalities is discussed. Malignant hyperthermia is a relatively newly defined problem that is associated with anesthesia. It is being recognized with increasing frequency, particularly in children with multiple musculoskeletal anomalies. The term itself is a misnomer. It is a drug-induced syndrome of hypermetabolism that may represent an inborn error of metabolism. Recognition, prophylaxis and crisis management are reviewed, and the use of dantrolene sodium in the care of patients with malignant hyperthermia is discussed. Because recognition of malignant hyperthermia is an important concern for the practicing urologist, the principles of identifying the patient at risk, as well as managing the crisis, should be familiar to the clinician.

Abnormalities, Multiple↗
PubMed1980

Severe pulmonary hypertension associated with macronodular (postnecrotic) cirrhosis and autoimmune phenomena.

The clinical and pathologic findings are reported in seven consecutive patients with progressive and fatal pulmonary hypertension which was not explained by predisposing cardiac or pulmonary diseases. Pulmonary arterial lesions consisted of atherosclerosis of the elastic pulmonary arteries, and medial hypertrophy and concentric laminar fibrosis of the muscular pulmonary arteries in seven patients, plexiform lesions in six patients and necrotizing vasculitis in one patient. Pulmonary emboli were not identified. Five patients had manifestations of autoimmune disease, including laboratory abnormalities (positive antinuclear antibody, positive latex agglutination for rheumatoid factor, hypergammaglobulinemia or antimitochondrial antibody) in four, necrotizing vasculitis in one, Raynaud's phenomenon in two and clinical evidence of multisystem collagen vascular disease in two. Five patients had liver disease which developed prior to or concomitant with the onset of pulmonary hypertension. At autopsy, one patient had prominent periportal fibrosis and four had macronodular (postnecrotic) cirrhosis (active in three and inactive in one). Four of these five patients with liver disease and pulmonary hypertension had evidence of autoimmune phenomena. The findings in the seven patients suggest an association between autoimmune disease, plexogenic pulmonary hypertension and liver disease of the chronic active hepatitis-postnecrotic cirrhosis type.

Adolescent↗
PubMed1980

Sodium nitroprusside-induced hypotension in radical thoraco-abdominal dissection of retroperitoneal lymph nodes.

Blood loss and replacement in 57 consecutive otherwise healthy young patients undergoing radical thoraco-abdominal dissection of retroperitoneal lymph nodes is reviewed. Twenty-five patients received nitroprusside (hypotensive group); 32 patients (normotensive group) did not. Blood loss varied significantly between the hypotensive and normotensive groups: the mean loss (+/- SEM) was 920 +/- 72 ml for the hypotensive group compared with 1341 +/- 98 ml for the normotensive group (P < 0.001). The total blood requirement for the normotensive patients was three times that of the hypotensive group. The difference between the two groups was more apparent in patients with advanced disease.

Adult↗