Retroperitoneal Müllerian carcinosarcoma.
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Biomedical subjects
Publications and source records attributed to R C Ross.
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A case of hepatoma induced by thorium dioxide (Thorotrast) is reported. The literature concerning neoplasia associated with this agent is reviewed, with emphasis on the long latent period before the development of these tumours and the equally long latent period which preceded the recognition of their iatrogenic nature.In particular, this report is intended to illustrate the diagnosis of such tumours on radiological and histological findings, provided that one is aware of their existence and familiar with the distribution and appearance of thorium dioxide deposits in the tissues. Such a diagnosis can be made without a history of thorium dioxide administration, which often may not be available.
The authors present a classic case of superficial spreading melanoma. Superficial spreading melanoma is the most commonly acquired cutaneous malignant melanoma. Its true etiology is unknown. Superficial spreading melanoma may remain in the epidermis with peripheral extension (radial growth phase) for as long as 5 years before invading deeper tissue layers. Definitive diagnosis is established through biopsy. Treatment, following biopsy, involves wide radical excision, and possibly lymphadenectomy and combination chemotherapy depending on the extent of the pathology.